Pancreatic Cancer Scrambles the Body Clock in Breathing and Heart Muscles
New research in mice shows that pancreatic cancer disrupts the circadian clocks of the diaphragm and heart, scrambling daily gene ...
Tag: metabolism
One Drug, Three Species: Direct AMPK Activation Extends Lifespan Across Evolution
A direct activator of the conserved energy sensor AMPK extends lifespan in yeast, worms and flies, with genetic controls confirming ...
Fluorescent Probes Let Scientists Watch Glucose Move Through Living Animals in Real Time
University of Bath researchers have created fluorescent boronic acid probes that, combined with multiphoton FLIM imaging, can track glucose changes ...
Approved Metabolism Drugs Rescue Disease Signs in SMA Mice
Three commercially approved metabolism-targeting drugs—pioglitazone, melatonin and insulin—improved survival, motor function, muscle size and hepatic pathology in Smn2B/- spinal muscular ...
Hidden hypothalamic hub discovered as the brain’s cold-driven metabolic control center
USF Health researchers have identified the dorsal posterior periventricular hypothalamic nucleus as a cold-sensing brain region that coordinates appetite, heat ...
Collagen Scaffold Helps Starved Tumours Switch Fuel and Evade Treatment
University of Sheffield researchers found that type I collagen in tumour scaffolding lets breast and pancreatic cancer cells switch fuel ...
Too Much Cysteine Kills Cells Through a Hidden Iron Overload in Mitochondria
A new Nature Metabolism study shows that excess cysteine kills cells by mobilizing ferritin iron, overloading mitochondria and collapsing iron–sulfur ...
Intermittent Fasting Shows Early Promise Against Huntington’s Disease in First Human Trial
A 12-week pilot trial found that an eight-hour time-restricted eating window was feasible, well tolerated, and associated with favorable clinical ...
Too Much Cysteine Comes at a Cost: Surplus Amino Acid Triggers Deadly Iron Overload in Cells
A new Nature Metabolism study shows that excess free cysteine disrupts mitochondrial iron homeostasis and triggers a distinct iron-dependent cell ...
Time-Restricted Eating Shows Early Promise in Huntington’s Disease Pilot Trial
A 12-week pilot study found that time-restricted eating was feasible and well tolerated in 20 people with early-stage Huntington's disease, ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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