Gut microbe metabolite worsens PCOS-like ovarian dysfunction under metabolic stress
A study links the gut bacterium Bacteroides fragilis and its metabolite indole-3-acetic acid to PCOS-like ovarian abnormalities that emerge only ...
Tag: metabolic stress
Fatty Diet Leaves Lasting Senescence-Like Scars in the Liver’s Regenerative Cells
A rat study finds that chronic high-fat diet feeding leaves liver organoid-forming regenerative cells locked in a senescence-like state with ...
Natural Compound α-Cyperone Shields Starved Neurons in Lab Study
In cultured primary mouse cortical neurons, the natural compound α-Cyperone restored survival after 96 hours of nutrient deprivation and strongly ...
Cysteine Dependence Reveals Metabolic Weakness in Small Cell Lung Cancer
Researchers at the University of Cologne have identified a shared metabolic vulnerability in small cell lung cancer, where all cell ...
SOS-independent prophage induction may spread resistance genes beyond DNA damage
A mini review identifies five SOS-independent routes by which prophages can activate and potentially disseminate antibiotic resistance genes without triggering ...
Triglyceride–glucose index identifies early metabolic stress and β-cell vulnerability in pediatric obesity
A cross-sectional study in children and adolescents with obesity links higher triglyceride–glucose index values to impaired insulin sensitivity and potential ...
Hidden Vascular Flaw in PCOS Emerges Only When Blood Sugar Rises
Endothelial cells derived from women with PCOS harbor a latent mitochondrial defect that hyperglycemia unmasks, and blocking the enzyme myeloperoxidase ...
When Chromatin Wobbles, Cells Pay a Metabolic Price, Study Finds
A PLOS Genetics study shows that destabilizing chromatin through a histone H3 mutation hyperactivates the nutrient-sensing TORC1 pathway and triggers ...
Cell Death Gets a Map: How mTORC2 Positions Mitochondria to Punch Holes in the Cell Membrane
Cell death is rarely a tidy affair, but a newly proposed framework argues that one recently identified form of lytic ...
Fasting Rewires the Brain’s Emotional Radar in Two Distinct Phases, EEG Study Finds
A 15-day supervised complete fasting study tracking event-related potentials in nineteen adults found that emotional reactivity shifts in two distinct ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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