Engineered E. coli strains keep fragile nitro compounds alive for green chemistry
Researchers have engineered E. coli strains carrying up to 15 nitroreductase gene deletions that retain and biosynthesize diverse nitroaromatic compounds, ...
Tag: metabolic engineering
Metabolism Holds the Key to Stronger CAR T Cell Therapies, Review Argues
A Nature Reviews Cancer review argues that metabolism, from CAR design and manufacturing conditions to the patient's diet, is a ...
Shotgun genetic engineering lets mammalian cells stumble onto new metabolic pathways
A Nature Biotechnology commentary highlights how shotgun genetic engineering, which tests vast random combinations of genes in mammalian cells, enabled ...
Shotgun genetic engineering lets mammalian cells test millions of designs at once
Researchers have developed shotgun genetic engineering, a multiplexed strategy that screens millions of combinatorial genetic designs in mammalian cells within ...
CRISPR Knockout of a Single Gene Supercharges Soybean’s Health-Boosting Isoflavones
Researchers used CRISPR/Cas9 to knock out the GmMYB100 repressor gene in soybean, boosting seed daidzein levels nearly threefold and genistein ...
Master Switch Found: Single Gene Controls the Purple Pigments of Black Goji Berry
Researchers have identified the R2R3-MYB transcription factor LrMYB113 as a key regulator that directly activates anthocyanin biosynthesis genes in black ...
Knocking Out One Glycolysis Gene Rewires a Marine Microbe to Make More DHA
Deleting the aldolase gene in the marine microbe Schizochytrium limacinum SR21 redirects carbon flux away from growth and toward a ...
Cells Balance Speed and Control When Budgeting Their Metabolic Enzymes
A new theoretical and cross-species study shows that cells allocate metabolic enzymes according to a Pareto trade-off between maximizing pathway ...
How a Tiny Osmolyte Could Shield Crops From Salt, Drought and Heat
A new review in Crop Health details how glycine betaine protects crops and microbial fertilizers from salt, drought, heat and ...
Engineering Life: How Synthetic Biology Is Rewriting Medicine, Farms and Factories
A sweeping new review charts how synthetic genetic circuits, synthetic chromosomes and engineered metabolism are transforming cancer therapy, drug delivery, ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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