Common ‘Forever Chemical’ PFNA Found to Ignite Gut Inflammation at Tiny Doses
New research shows that low-dose exposure to the forever chemical PFNA worsens intestinal inflammation by activating a caspase-11-dependent NLRP3 inflammasome ...
Tag: macrophages
Two Forms of the Estrogen Receptor Play Opposing Roles in Lupus Inflammation
New research shows that two splice variants of estrogen receptor alpha, ERα66 and ERα46, exert opposing, cell-type-specific and potentially sex-specific ...
Spinal Cord Injury Signal Found to Trigger Bone Growth in Muscle
A new study identifies adrenomedullin released from the injured spinal cord as the molecular trigger that drives abnormal bone formation ...
Single Temporary Stimulus Steers Cell Fate Without Altering Genes
KAIST researchers developed NUDGE, a computational framework that redirects cell fate with a single temporary intervention by harnessing the natural ...
Cellular Recycling Switch SIRT1-FOXO1 May Hold Key to Taming Brain Inflammation
New research shows that the SIRT1-FOXO1 signaling axis acts as a molecular brake on excessive mitophagy and glycolytic metabolism in ...
Spatial Cell Atlas Reveals How a Deadly Tapeworm Rewires the Liver’s Immune Defenses
By combining single-cell RNA sequencing with Visium HD spatial transcriptomics, researchers have built the first spatially resolved atlas of immune ...
Macrophages move captured proteins onto their own surface during live-cell uptake
New research shows that macrophages can transfer functionally active proteins from engulfed live cells onto their own surface rather than ...
Macrophage Gadd45b Emerges as Key Driver of Inflammation-Linked Liver Cancer
A refined experimental model of metabolic dysfunction-associated steatohepatitis-driven liver cancer identifies macrophage Gadd45b as a central regulator of inflammation-driven tumor ...
Repurposed cancer and blood pressure drugs show promise against artery-clogging foam cells
Researchers repurposed the approved drugs talazoparib, tivozanib and isradipine as candidate inhibitors of VAV2 signaling that reduced oxidized LDL uptake ...
Nerve Injury Protein NINJ2 Emerges as a Brake on Inflammatory Bowel Disease
Researchers found that the nerve repair protein NINJ2 protects mice from inflammatory bowel disease by suppressing ZBP1-driven PANoptosis in macrophages.
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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