MIF Inhibitor ISO-1 Cuts Liver Reperfusion Injury in Rat Transplant Model
A small-molecule inhibitor of macrophage migration inhibitory factor reduced early liver injury and improved graft microcirculation in a rat model ...
Tag: macrophages
Scientists pinpoint THBS1 as a driver of fat tissue scarring in obesity and diabetes
A single-nucleus atlas of human visceral fat identifies THBS1-expressing stem cells and adipocytes as drivers of fibro-inflammatory remodeling in obesity ...
Single-cell map reveals immune-fibrotic imbalance driving COPD
A single-cell RNA sequencing analysis of 101,009 cells identifies 17 cell subtypes and reveals reduced macrophage and fibroblast signaling alongside ...
Sepsis Study Points to THBS1 as a Myeloid-Linked Marker of Poor Outcomes
An integrated transcriptomic and computational study identifies THBS1 as a candidate myeloid-associated molecule linked to inflammatory dysregulation and poorer survival ...
Liraglutide regulate osteogenesis-resorption via macrophage under compressive stress
A new cell study reports that liraglutide suppresses pressure-induced osteoclast differentiation and inflammation in macrophages while indirectly promoting osteoblast marker ...
Same Drug, Different Cells: Why mTOR Inhibition in Plaques Defies Simple Rules
A new review argues that mTOR's effects in atherosclerotic plaques depend on cell state, plaque niche, signalling complex and drug ...
Macrophages, Fibroblasts and Cancer Cells Conspire to Switch On a Tumor-Fueling Protein in Pancreatic Cancer
A new study shows that cooperative signals from macrophages, stellate cells and cancer cells switch on the tumor-promoting protein CHI3L1 ...
Type I Interferon Signaling Helps Clear Early Lyme Disease Infection in Mice
New mouse research shows that type I interferon signaling restricts early Borrelia burgdorferi expansion by boosting macrophage uptake and killing, ...
Salmonella silences inflammatory genes transcriptionally, but macrophage translation escapes
A time-resolved study of Salmonella-infected mouse macrophages shows the bacterium's SPI-1 injectisome suppresses the TLR4-dependent transcriptional response during the first ...
Efferocytosis triggers a transient IKKβ signal that reprograms mouse macrophages toward tissue resolution
A mouse study reports that engulfment of apoptotic cells briefly activates an IKKβ–NFκB/p38 pathway in macrophages, driving IL-10, regulatory T ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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