RNA Methylation Restores Heart Function in Progeria Mice
Restoring cardiac METTL14 reduced inflammation and fibrosis while improving survival in two mouse models of progeria.
Tag: m6A
Hidden Metabolite Switches on RNA Draw $5.5 Million NIH Transformative Award
Weill Cornell Medicine's Dr. Samie Jaffrey has received a five-year, $5.5 million NIH Director's Transformative Research Award to map how ...
Within 24 Hours, an mRNA Booster Reshapes the Immune System—and Naive CD4 T Cells May Hint at Breakthrough Infection Risk
A new mass cytometry study reveals that mRNA booster vaccination triggers rapid, lineage-specific immune remodeling within 24 hours, with early ...
Epigenetics and Metabolism: The Two-Way Conversation Driving Liver Cancer
A new review in the Chinese Medical Journal maps how epigenetic modifications and metabolic reprogramming fuel each other in hepatocellular ...
DNMT1 Regulates Testosterone Synthesis in Aged Rat Leydig Cells via FTO‐Mediated HSP90AA1 m6A Levels
Aging Cell study reveals how declining DNMT1 triggers FTO-mediated m6A changes that silence HSP90AA1 and AKT signaling, driving testosterone loss ...
Hidden Molecular Shield Lets Lung Cancer Cells Dodge Copper-Driven Cell Death
Researchers have mapped a USP11-IGF2BP2-ATOX1 molecular axis that shields non-small cell lung cancer cells from copper-induced cuproptosis, revealing new drug ...
Ribosomal RNA Tag and a Detox Enzyme Form a Deadly Cancer Survival Circuit
A new review describes how the RNA methyltransferase METTL5 and the detox enzyme MGST1 form a signaling axis that helps ...
Hidden Ubiquitin Switch That Lets Brain Tumors Evade Immune Attack Is Revealed
New research reveals that the ubiquitin ligase BTRC destroys the RNA-binding protein hnRNPC, whose stabilization of PSD4 mRNA boosts PD-L1 ...
Super Elongation Complex Found to Switch On Genes That Transform Cell Identity
New research shows that the Super Elongation Complex drives both stem cell reprogramming and neural differentiation by releasing paused RNA ...
Fly Study Reveals How the RNA Modifier Mettl16 Shapes Development and Fertility
New research in fruit flies shows that the RNA methyltransferase Mettl16 is dispensable for survival but essential for fertility, acting ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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