ABCA1 cholesterol trafficking implicated in Parkinson’s neurodegeneration in mice
Human postmortem tissue, cultured cells and mouse experiments implicated abnormal ABCA1-dependent cholesterol trafficking in Parkinson’s-related neurodegeneration.
Tag: lysosomes
Kidney Aging Enzyme PLA2G15 Emerges as New Target Against Cellular Senescence
Researchers at Amsterdam UMC report that disrupting the lysosomal enzyme PLA2G15 reduces stress-induced senescence and reshapes BMP phospholipid metabolism in ...
Scientists Catch Muscle Aging in a Dish: A New Lab Model of Skeletal Muscle Senescence
Researchers at the Federal University of Rio de Janeiro have built a primary chick muscle cell culture model in which ...
Aging Cells Fail at the Final Step of Cellular Recycling, Study Finds
A new study of human skin fibroblasts from donors aged 20 to 96 shows that autophagy's early stages remain intact ...
Fluorescent Probes Can Quietly Rewrite the Biology They Measure
A new review argues that the same molecular features that make fluorescent probes bright and targetable also perturb the living ...
Mitochondrial protein CHCHD2 emerges as a guardian of the aging brain
New research shows that the age-related decline of the mitochondrial protein CHCHD2 disrupts the mitochondria-lysosome axis and drives proteostatic collapse ...
How a Pathogen Hijacks Nerve Signals to Break Down a Worm’s Skin
Researchers discovered that the bacterium Pseudomonas aeruginosa exploits neuronal signaling in C. elegans to impair lysosomal function and disrupt collagen ...
Aging Cells Lose Their Recycling Machinery, Letting Senescent Cells Pile Up
New research in Nature Aging shows that the age-related decline of chaperone-mediated autophagy distorts the senescent cell secretome and disables ...
Brain Cells Have a Fat Sensor That Keeps Their Recycling Plants Running
New research reveals that the nutrient sensor CPT1C protects hypothalamic neurons by restraining the BMP-hydrolyzing enzyme ABHD6, preserving the endolysosomal ...
Scientists Find Druggable Switch That Controls the Cell’s Master Recycling Regulator TFEB
A Nature study from TIGEM reveals a previously unknown TBK1-ULK1 signaling pathway that controls the master recycling regulator TFEB, exposing ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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