Cellular Recycling Pathway Emerges as Central Driver of Ageing and Disease
A new review argues that chaperone-mediated autophagy, the cell's most selective protein degradation pathway, acts as a master regulator of ...
Tag: lysosome
Lysosome Gene Signature Offers New Prognostic Tool for Lung Cancer
Researchers have built a 13-gene lysosome-related signature that predicts survival, immune landscape, and drug responses in lung adenocarcinoma patients.
Broken Cellular Recycling Plants Emerge as Common Thread in Neurodegenerative Disease
A new review in Nature Reviews Neurology argues that defective lysosomal function is a central, genetically validated driver of Parkinson ...
Rare Disease Protein Revealed as Key Enzyme in Cellular Lipid Recycling
New research identifies the Batten disease protein CLN8 as a stereospecific acyltransferase that initiates the biosynthesis of the essential lysosomal ...
Batten Disease Protein CLN8 Reveals a Hidden Route for Making Key Lipids
Two new studies show that the Batten disease protein CLN8 catalyzes a key step in a non-canonical phospholipid synthesis pathway ...
Developmental Gene PAX9 Turns the Body’s Recycling System Into a Cancer Cell Killer
A new study shows that the developmental transcription factor PAX9 acts as a tumour suppressor in oral squamous cell carcinoma ...
ER Domains Send a Molecular Repair Crew to Mend Damaged Lysosomes
New research shows that PI3P generated on endoplasmic reticulum microdomains recruits the ATPase DFCP1 to repair damaged lysosomal membranes.
Breakthrough Discoveries Illuminate Cellular Health: Unveiling the Recycling Mechanism within Cells
Recent research from the Tata Institute of Fundamental Research in Mumbai, India has shed light on an essential cellular process ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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