Traditional Chinese Formula Chuining Slows Pituitary Tumor Growth by Suppressing KIF20B
A new study shows that the traditional Chinese medicine formula Chuining inhibits pituitary tumor growth, promotes apoptosis, and suppresses glycolysis ...
Tag: LDHA
TNFAIP3 curbs lactylation-driven DNA repair and boosts chemotherapy sensitivity in ovarian cancer
A new Cellular Oncology study reports that the tumor suppressor TNFAIP3 restrains lactylation-linked DNA damage repair and increases ovarian cancer ...
TRIP13 shields a key metabolic enzyme from destruction, helping colorectal cancer adapt and resist chemotherapy
TRIP13 protects LDHA from FBXW7-mediated degradation, sustaining a lactate-driven antioxidant program that helps colorectal cancer cells adapt to hypoxia and ...
Lactate emerges as both warning sign and driver of kidney injury after heart surgery
A new iScience study combining machine learning on over 6,500 patient records with rat and cell experiments shows that lactate ...
Follicular Fluid Proteins Reveal Metabolic and Immune Clues in Ovarian Syndrome
Using 4D label-free proteomics, researchers identified 33 differentially expressed proteins in follicular fluid from patients with polyendocrine metabolic ovarian syndrome, ...
Enzyme USP16 Drives Pancreatic Cancer Growth and Gemcitabine Resistance Through a Glycolytic Switch
Researchers have identified a METTL3/IGF2BP1-USP16-FUBP1-LDHA regulatory axis that drives glycolysis-dependent progression and gemcitabine resistance in pancreatic ductal adenocarcinoma, highlighting USP16 ...
Lactate-Fueled Tumor Neighborhoods: Glycolysis Hotspots Recruit Neutrophils in Lung Cancer
A multi-omics study maps lactate-glycolysis activity in lung adenocarcinoma to fibroblasts and neutrophils, revealing spatially organized metabolic niches linked to ...
Neurexophilin 4 Emerges as a Molecular Driver of Kidney Cancer Through PI3K/AKT-Controlled Glycolysis
New research reveals that the protein neurexophilin 4 drives the growth, invasion and metabolic reprogramming of clear cell renal cell ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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