How the Gut-Liver Axis Prepares the Liver for Cancer Metastasis
A new review maps how gut bacteria, their metabolites, and liver-resident cells collaborate to build a pre-metastatic niche that primes ...
Tag: Kupffer cells
Bile Acid Sensor FXR Drives Liver Regeneration by Rebuilding Its Immune Cell Army
New research shows that the bile acid receptor FXR coordinates monocyte recruitment and Kupffer cell proliferation through CCR2 and CSF1/PI3K/Akt ...
Microplastics Overwhelm Liver Immune Cells and Derail Metabolism in Mice
A twelve-week mouse study shows that microplastics and nanoplastics accumulate in liver macrophages and disrupt metabolism in strikingly different ways ...
New Immune Checkpoint Discovery Explains Why Gastric Cancers Ignore PD-1 Drugs
Researchers created a mouse model of refractory gastric cancer and discovered that the YAP-driven BST2 protein reprograms neutrophils and Kupffer ...
Routine Liver Tests May Reveal Which Sepsis Patients Face the Deadliest Risk
A new commentary in Intensive Care Medicine argues that routine liver tests, particularly the De Ritis ratio, can identify sepsis ...
Liver Macrophages Carrying Apolipoprotein E Act as a Molecular Brake That Drives T Cell Exhaustion and Preserves Transplant Tolerance
A specialized APOE-producing Kupffer cell population in transplanted livers restrains rejection by driving attacking CD8-positive tissue-resident memory T cells into ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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