Diabetes Drug Metformin Shows Promise Against Deadly Pancreatitis in Obesity, Gut Microbe Study Finds
New research in the Journal of Translational Medicine shows that metformin reduces pancreatic and lung injury in obese mice with ...
Tag: Journal of Translational Medicine
Engineered CAR-T Cells That Make Their Own IL-2 Show Stronger Staying Power Against Pancreatic Cancer
A preclinical study shows that CAR-T cells engineered to secrete an Fc-fused IL-2(C125S) variant persist longer, retain mitochondrial fitness, and ...
Dual-Target CAR-T Cells Outsmart Antigen Shedding in Ovarian Cancer
Researchers have engineered biparatopic CAR-T cells that target both full-length MUC1 and the truncated MUC1β stub exposed after MUC1α shedding, ...
Muscle Symptoms May Anchor a Hidden Web of Body-Wide Dysregulation in ME/CFS
A new analysis of 736 ME/CFS patients finds that muscle symptoms are statistically embedded in a latent physiological dysregulation factor ...
AI Knockout Screen Reveals GSTP1 as a Driver of Lung Cancer Immunotherapy Resistance
A transformer-based in-silico gene knockout screen across 109 cell types has identified GSTP1 as a key driver of immunotherapy resistance ...
Lupus Patients With Stubborn Symptoms May Resemble ME/CFS, New Framework Suggests
A new commentary in the Journal of Translational Medicine proposes a testable research phenotype linking persistent symptoms in long-standing lupus ...
Hidden Bacteria Inside Stomach Tumors May Signal How Aggressive Gastric Cancer Will Be
A dual-sequencing study of gastric tumors reveals a distinctive bacterial signature linked to cancer stage and biomarker levels.
Fasting Rewires the Brain’s Emotional Radar in Two Distinct Phases, EEG Study Finds
A 15-day supervised complete fasting study tracking event-related potentials in nineteen adults found that emotional reactivity shifts in two distinct ...
Protein Axis That Shields the Cornea Offers New Hope Against Dry Eye Pain
A newly identified PPP4C-CALML5 protein axis restores corneal nerves, tear secretion and pain relief in a mouse model of dry ...
Traditional Medicine Alkaloid Sophocarpine Shows Promise Against Blinding Retinal Scarring
A new study shows that sophocarpine, an alkaloid from Sophora flavescens, reduces subretinal fibrosis in mice by blocking TGF-β–driven epithelial-mesenchymal ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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