RGS Proteins Emerge as Hidden Architects of the Tumor Microenvironment
A new review in the Journal of Translational Medicine details how RGS proteins, the off switches of GPCR signaling, reshape ...
Tag: Journal of Translational Medicine
One Gene Links Five HLA-B27 Diseases, Study Finds
A large computational and experimental study has identified ABCD2 as the only gene biomarker shared across five HLA-B27-associated immune-mediated diseases, ...
Low Oxygen Inside Tumors Fuels Cervical Cancer Growth and Cisplatin Resistance, Study Finds
Researchers at Chongqing Medical University report that hypoxia silences the tumor suppressor CCNDBP1 in cervical cancer, activating a USP11–Nrf2 antioxidant ...
RNA-Binding Protein ADAR2 Throttles Bladder Cancer Spread by Destroying Fat-Making Enzyme Message
A new study shows that the RNA-binding protein ADAR2 suppresses bladder cancer metastasis by destabilizing FASN mRNA and curbing fatty ...
Immune Webs of DNA May Drive Brain Bleeding After High-Sugar Stroke
New research shows that neutrophil extracellular traps driven by high blood sugar worsen bleeding complications after ischemic stroke, and that ...
Viral Mimicry Revealed: SARS-CoV-2 T Cells Also Recognize Tumor Antigens
Single-cell TCR sequencing shows that SARS-CoV-2-specific CD8 T cells recognize a tumor-associated antigen through molecular mimicry, supporting viral-mimic cancer vaccines.
Common Sweetener Sucralose Shows Surprising Ability to Calm Autoimmune Attacks in Vitiligo
New research shows the artificial sweetener sucralose slows autoimmune depigmentation in mice and suppresses human CD8+ T cell activity by ...
Tight Junction Protein Revealed as Hidden Brake on Kidney Cancer Growth
Researchers report that the tumor-suppressive protein TJP2 stabilizes TIMM21, which boosts SPRY4 and dampens ERK1/2 signaling to restrain clear cell ...
Nerves and Tumors Talk: New Review Maps How Liver Cancer Invades Neural Highways
A new review in the Journal of Translational Medicine maps how perineural invasion may drive hepatocellular carcinoma aggression, organizing the ...
How a Single Amino Acid Pathway May Steer Autoimmune Disease
A new review in the Journal of Translational Medicine details how the glutamine-glutamate metabolic axis regulates immune cell fate and ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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