Scientists Uncover a Fat-Metabolism Switch That Fuels Esophageal Cancer and Blunts Chemotherapy
A new study shows that the transcription factor ELF4 activates the enzyme UGT8, reshaping sphingolipid metabolism to drive esophageal squamous ...
Tag: Journal of Translational Medicine
Cancer Cells Turn Fat Factories: SOX9 Fuels Colorectal Cancer Spread Through Lipid Rewiring
New research reveals that the transcription factor SOX9 drives colorectal cancer metastasis by directly activating the fat-synthesizing enzyme FASN, and ...
Better Survival in Mice Is Not Proof of Senolytic Anti-Ageing Success, Researchers Warn
A new letter in the Journal of Translational Medicine argues that a senolytic vaccine study showed real therapeutic benefit in ...
Enzyme Duo Revealed as Hidden Driver of Ovarian Cancer Growth
Researchers have discovered that the deubiquitinase USP12 stabilizes the Rab GTPase-activating protein TBC1D22A, activating PI3K-AKT-mTOR signaling and driving ovarian cancer ...
How Tumor Mechanics Control Whether Mitochondrial DNA Fuels or Fights Cancer Immunity
A new review in the Journal of Translational Medicine proposes that the physical mechanics of solid tumors govern whether mitochondrial ...
From Bedside Question to Breakthrough: A Step-by-Step Roadmap for Translational Medical Research
Researchers at Dalian Medical University have proposed a five-step, clinical question-driven strategy that turns translational medicine from an abstract concept ...
Ancestry Shapes the Side Effects of Melanoma Immunotherapy, Study Finds
A genomic study of 841 melanoma patients at NYU Langone Health found that underrepresented minority patients experienced significantly more immune ...
Gut Fungi Leave a Distinct Signature in Gout, Metagenomic Study Finds
A reanalysis of 307 fecal metagenomic samples reveals that gout patients carry distinct gut fungal signatures linked to bacterial communities ...
T Cell Receptor Sequencing Reveals Immune Fingerprints in Children with Mycoplasma Pneumonia
High-throughput sequencing of the T cell receptor beta CDR3 repertoire in children with Mycoplasma pneumoniae pneumonia reveals reduced immune diversity, ...
Single-Cell Atlas of Glioma Reveals Astrocyte Gene TTYH1 as a Hidden Tumor Suppressor
An integrated single-cell and spatial multi-omics study of glioma identifies the astrocyte-associated gene TTYH1 as a tumor suppressor that impedes ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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