Observational cohort finds uncertain fetal risk after first-trimester JAK inhibitor exposure
A German Embryotox observational cohort found two major congenital anomalies among 32 live births after first-trimester JAK inhibitor exposure, but ...
Tag: JAK inhibitors
CAR-T Cells Linger in the Gut and Drive Severe Intestinal Inflammation, Mount Sinai Study Finds
Chimeric antigen receptor T cell therapy has redefined the treatment of multiple myeloma, offering deep and durable remissions to patients ...
New Guidelines Reshape Care for Rare Bone Marrow Cancer Myelofibrosis
The American Society of Hematology has released ten new recommendations for myelofibrosis care, covering expanded molecular testing, JAK inhibitor use, ...
Standard-Dose Infliximab Edges Out Ciclosporin in Rescue Therapy Review for Severe Ulcerative Colitis
A new network meta-analysis of 18 studies finds standard-dose infliximab associated with lower colectomy odds than ciclosporin in steroid-refractory acute ...
Targeted Biologics Show Promise for Severe Allergy in Rare Genetic Immune Disorders
A new systematic review of 172 patients finds that dupilumab, omalizumab, and JAK inhibitors can meaningfully control severe atopic disease ...
Oxidative Stress Takes Center Stage in Vitiligo as Scientists Target the Nrf2 Antioxidant Pathway
A new review in the Archives of Dermatological Research positions oxidative stress and the Nrf2 antioxidant pathway at the center ...
JAK Inhibitors Emerge as Promising Option in First Systematic Review of Nail Lichen Planus Treatments
A systematic review of 269 patients finds that JAK inhibitors, retinoids, and low-dose naltrexone outperform the corticosteroid therapies that dominate ...
New Therapies Reshape Treatment of Rare Childhood Skin Sclerosis
A new narrative review maps how methotrexate, biologics, and JAK inhibitors are transforming the management of pediatric morphea, a rare ...
Crohn’s Disease May Be Driven by a Self-Reinforcing Loop Between Gut Barrier, Immunity and Microbes
A new review proposes that Crohn's disease is sustained by self-reinforcing feedback loops linking epithelial barrier failure, immune hyperactivation and ...
Interferon-Gamma Emerges as a Potential Hub Linking Inflammation to Fibrosis in Sjögren’s Lung Disease
A new review proposes that interferon-gamma acts as a regulatory hub connecting immune activation, inflammatory amplification, and fibrotic remodeling in ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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