Nanoscale map charts the spatial organization of the human cell surface
Proximity labeling of 85 antigens on human immune cells has produced a nanoscale map of the surface proteome, revealing functional ...
Tag: interferon signaling
TREX1 enzyme shields tumors by destroying immune-activating DNA fragments
New research shows that the TREX1 exonuclease suppresses anti-tumor immunity in mice by degrading short, MRE11-derived cytosolic DNA fragments that ...
Single amino acid in PEDV Nsp8 helps the virus evade a host antiviral factor
Researchers report that alanine at position 53 of PEDV Nsp8 strengthens the virus's suppression of the host antiviral factor DTX3L, ...
Deleting TBK1 Entirely Slows Disease Progression in ALS Model Mice
Complete deletion of the ALS-linked gene TBK1 suppresses microglial activation and extends disease duration in SOD1-ALS model mice, a new ...
Checkpoint Gene Signatures Reveal Three Melanoma Immune Types With Sharply Different Survival Odds
A multi-cohort re-analysis of melanoma transcriptomes and single-cell immune data links coordinated checkpoint-gene expression to longer overall survival, treatment-related immune ...
BRCA Mutations Shape Immune Landscapes in Ovarian Cancer, Spatial Study Finds
A multi-omics study combining genomics and spatial transcriptomics finds that BRCA-mutated high-grade serous ovarian cancers show stronger interferon and inflammatory ...
Synthetic organelle records transient gene activity in human cells
A mitochondria-anchored synthetic organelle captured up to 90% of expressed gene transcripts in human cells and preserved transient interferon-response histories ...
Review maps hepatitis E receptor networks and immune evasion
A 2026 review finds that hepatitis E virus enters cells through overlapping receptor networks and counters innate immunity through activities ...
Metformin Leaves No Robust Gene Signature in Small AMD Trial
A small randomized trial sub-study found no significant individual-gene changes after 18 months of metformin in older adults with age-related ...
Centromere Protein IFIT3 Emerges as a Driver of Mitochondrial Dysfunction in Down Syndrome
Researchers have identified the interferon-stimulated protein IFIT3 as a highly dysregulated centromere-proximal protein in fetal Down syndrome cells, showing that ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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