Isoleucine and Valine, Not Leucine, Drive T Cell Proliferation Through c-Myc
A mouse study finds that isoleucine and valine, rather than leucine, sustain c-Myc expression and proliferation in activated CD8 T ...
Tag: integrated stress response
Molecular Neuroscience Editors Map Current Progress and Future Challenges
Editors of a Frontiers in Molecular Neuroscience Research Topic survey studies linking synaptic, immune and systems-level molecular mechanisms to neurological ...
New Mouse Model Reveals How RMND1 Mutations Disrupt Mitochondrial Energy Production
The first knock-in mouse carrying the recurrent human RMND1 p.(Asn238Ser) mutation recapitulates severe multisystem mitochondrial disease, revealing widespread OXPHOS defects ...
Damaged Mitochondria and Runaway Glycolysis Reshape Immune Responses, Review Finds
A new review proposes that compensatory upregulation of fermentative glycolysis following mitochondrial dysfunction integrates and modulates the immune responses triggered ...
Multi-omics study links autophagy and ER stress to PFOA toxicity in sperm precursor cells
A multi-omics study in GC-1 spermatogonial cells links PFOA exposure to altered autophagy, ER stress signaling and oxidative imbalance, with ...
Low pyruvate carboxylase makes respiration-deficient tumours dependent on asparagine
A Nature Metabolism study shows that respiration-deficient cells with low pyruvate carboxylase become dependent on asparagine, a vulnerability exploited by ...
Cellular Stress Signals Shift in Women With Severe Pregnancy Vomiting
A prospective case-control study finds that pregnant women with hyperemesis gravidarum have significantly lower circulating ATF-4 levels than healthy controls, ...
Cellular Stress Hubs Help Oral Cancer Spread, Study Finds
New research shows that stress-induced eIF2α phosphorylation drives stress granule formation that promotes growth and metastasis in oral squamous cell ...
Experimental Drug DNL343 Fails to Slow ALS Progression in Randomized Trial
A randomized clinical trial in JAMA Network Open found that 200 mg per day of DNL343, an eIF2B activator, did ...
Tiny RNA Hubs May Steer Inflammation in Aging Cells
A new review argues that stress granules and their RNA-binding proteins act as context-dependent modulators of cellular senescence and inflammation ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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