EGF-depleting vaccine plus nivolumab shows survival signal in advanced NSCLC
A phase II trial reports 11.9-month median overall survival with CIMAvax-EGF plus nivolumab in previously treated advanced NSCLC, with the ...
Tag: Immunotherapy
New Protocol Tracks Natural Killer Cells Attacking Tumors in 3D, One Cell at a Time
A newly published protocol details a three-component tumor organoid co-culture system with 3D live-cell imaging that quantifies single-cell dynamics of ...
Lipid nanoparticles emerge as leading siRNA carriers for liver cancer therapy
A new review outlines how lipid-based nanomedicines could deliver pathway-specific siRNA to treat hepatocellular carcinoma, highlighting delivery design, preclinical candidates ...
Gut Microbes Send Chemical Signals That Shape Cancer and Metabolic Disease
A new review details how microbiome-derived metabolites such as short-chain fatty acids, secondary bile acids, and tryptophan derivatives regulate host ...
Dietary restriction reshapes melanoma immune landscape and may boost immunotherapy response
A transcriptomic study links dietary restriction-associated immune and vascular changes in melanoma tumors to better prognosis and improved immunotherapy response.
AlphaFold 3 Structures Can Guide T-Cell Receptor Engineering, With Caveats
A benchmark of 438 TCR–pMHC mutations shows experimental structures remain the best input for binding-affinity predictors, while AlphaFold 3 mutant ...
Taurine-loaded nanoparticles combine photothermal therapy and immune modulation against gastric cancer in mice
Hyaluronic acid-modified taurine-polydopamine nanoparticles combined photothermal therapy with taurine-driven immune modulation to suppress gastric tumors in mice.
CD4+ Cytotoxic T Cells Emerge as Double-Edged Effectors in Health and Disease
A new review summarizes how CD4+ cytotoxic T cells act as both protective and pathological effectors, and why targeting them ...
Lactate Drives Immune Evasion in Pancreatic Cancer via TRMT6-SIRT5 Axis
A new study reports that lactate in the pancreatic tumor microenvironment promotes metabolic reprogramming and PD-L1 upregulation through the TRMT6-SIRT5 ...
Researchers call for a microbiome moonshot to tackle chronic disease
An international team of researchers, including Rutgers microbiologists, has outlined ten priorities in Nature Medicine for testing how the human ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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