French Bulldog Brain Tumors Show Distinct Gene Expression From Related Breeds
RNA sequencing of 18 canine brain tumors reveals 45 genes expressed at different levels in French bulldogs compared with boxers ...
Tag: Immunotherapy
Engineered IL-6-Responsive CAR Macrophages Boost CAR-T Cell Activity Against Solid Tumors
Engineered IL-6-responsive CAR macrophages enhanced CAR-T cell antitumor activity, matrix remodeling, and survival in preclinical solid tumor models.
Gene Expression Differences in Canine Brain Tumours Revealed by Breed Comparisons
An analysis of RNA from high grade oligodendroglioma tissue found 31 genes differentially expressed between French Bulldogs and closely related ...
Adding PD-1 Inhibitors to Rectal Cancer Therapy Linked to Higher Complete Response Rates
A retrospective study of 84 rectal cancer patients found that adding a PD-1 inhibitor to neoadjuvant chemoradiotherapy was associated with ...
Fibroblasts That Show Tumors’ IDs May Be Shapeshifters, Not Fixed Subtypes
A new perspective argues that antigen-presenting fibroblasts in gastrointestinal tumors are reversible states whose immune role depends on unmeasured co-stimulatory ...
Lab-Grown Tumor Organoids With Immune Cells Aim to Predict Immunotherapy Response
A new review examines how patient-derived tumor organoids retaining immune cells could improve preclinical prediction of immunotherapy response while noting ...
RPL22 Mutations May Shape Drug Sensitivity in Aggressive Endometrial Cancer
Researchers found RPL22 mutations in 42% of undifferentiated/dedifferentiated endometrial carcinoma samples and showed in cell and xenograft models that the ...
Gene Screens in Aged Mice Reveal Two Distinct Routes to Restore Tumor-Fighting T Cells
Genetic screens in aged mice identify Dusp5 and Zfp219 as regulators whose deletion can restore anti-tumor T cell function, with ...
Synthetic Viral RNA Shrinks NF1 Brain Tumors by Reprogramming Immune Cell Signaling
Poly(I:C), a synthetic double-stranded RNA, durably suppressed NF1-associated optic pathway glioma growth in mice by engaging TLR3 and MDA5 pathways ...
EGF-depleting vaccine plus nivolumab shows survival signal in advanced NSCLC
A phase II trial reports 11.9-month median overall survival with CIMAvax-EGF plus nivolumab in previously treated advanced NSCLC, with the ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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