Two-Drug Combo Supercharges Liver Cancer Therapy in Preclinical Study
A preclinical study reports that combining the kinase inhibitor regorafenib with the small-molecule PD-1/PD-L1 inhibitor BMS-1 synergistically suppresses the growth, ...
Tag: Immunotherapy
Scientists Uncover Why a Key Antitumor T Cell Loses Its Fight in Ovarian Cancer
A new study links CEACAM1 expression and dysregulated SHP-1, LCK, and ZAP70 signaling to the functional exhaustion of follicular cytotoxic ...
Cancer Drug Triggers Rare Blistering Skin Disease That Masqueraded as Something Else
A new case report describes how the immunotherapy drug pembrolizumab triggered pemphigoid nodularis, a rare blistering skin disease that initially ...
Chemical Tags on Tiny Vesicles May Shape How Cancer Spreads
A new review in the Journal of Translational Medicine details how post-translational modifications such as ubiquitination, phosphorylation, acetylation, and SUMOylation ...
IDO1 Inhibitor Plus Melanoma Vaccine Fails to Boost Tumor-Fighting T Cells in Trial
A phase II pilot trial found that the IDO1 inhibitor epacadostat safely reduced kynurenine-to-tryptophan ratios in advanced melanoma patients but ...
Immune-Boosting Gel Paired with Radiation Shows Early Promise in Dogs with Head and Neck Cancer
A pilot study found that intratumoral injections of the toll-like receptor 7/8 agonist CB101 combined with hypofractionated radiation therapy were ...
Sound-Activated Nanoparticles Meet Patient-Derived Tumor Organoids in Precision Cancer Therapy
A new review details how ultrasound-triggered nanomaterials paired with patient-derived tumor organoids could enable non-invasive, personalized cancer therapy tested on ...
Safer Macrophage-Based Immunotherapy Combo Shows Promise Against Ewing Sarcoma
Researchers have replaced the toxic components of a macrophage-directed immunotherapy for Ewing sarcoma with cyclophosphamide and the erythrocyte-sparing antibody lemzoparlimab, ...
AI Designs Working T-Cell Receptors That Could Transform Immunotherapy Screening
Researchers have developed a transformer-based AI model that generates functional T-cell receptor sequences tailored to specific epitopes, with laboratory tests ...
Tiny Bubble Messengers Could Transform How Gastric Cancer Is Detected and Treated
A new review maps how extracellular vesicles drive gastric cancer progression and how engineered versions could become diagnostics and drug ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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