Tag: immunosuppressive tumor microenvironment

BRAF inhibitor-resistant melanoma cells release M-CSF and remodel the immune microenvironment, and blocking this signal improved drug efficacy in mouse ...

A new study links tumor-cell RNF128 to reduced CD8-positive T-cell infiltration and poorer immune checkpoint blockade responses in bladder cancer.

A new review explains how regulatory T cells are co-opted by ovarian tumors to suppress immunity, and how precision therapies ...

A preclinical study reports that formononetin from Jianpi Tongluo Formula suppresses colorectal cancer progression by inhibiting M2 tumor-associated macrophage polarization ...

A machine-learning 15-gene lactylation signature predicts prognosis and drug response in clear cell renal cell carcinoma, with CCNA2 identified as ...

Pancreatic ductal adenocarcinoma remains one of medicine's most unforgiving diagnoses. Despite decades of progress in surgical technique and chemotherapy, the ...

KIT-led researchers show that inactivating the CD44 molecule reprograms tumor-promoting fibroblasts in pancreatic cancer, reducing fibrosis and immunosuppression and shrinking ...

A 2026 review proposes that bacteriophage-derived delivery, barrier-breaching and immune-stimulation features could help oncolytic viruses penetrate cold tumors and stimulate ...

Multi-omics study reveals how myeloid-derived IL6/JAK/STAT3 signaling creates a spatially organized immunosuppressive niche that drives colitis-associated carcinogenesis, offering a potential ...

A ginseng-derived saponin suppresses pancreatic cancer in preclinical models by blocking the PI3K-AKT pathway and preventing macrophages from adopting a ...