Wasp venom immunotherapy quiets basophils by reshaping IgG4 and Fc receptors
A prospective study of 24 patients found that the first month of Vespula venom immunotherapy selectively suppresses venom-specific basophil activation ...
Tag: immune tolerance
Leukemia inhibitory factor shifts immune checkpoint gene expression in abortion-prone mice
A mouse study finds that leukemia inhibitory factor alters the expression of several immune checkpoint-related genes in the decidua of ...
Mutated neutrophils may trigger immune self-attack in lupus patients
New research in Nature finds that 33 of 34 lupus patients carried neutrophils with RNA splicing mutations producing neoantigens that ...
Beyond Apoptosis: How Inflammatory Cell Death Pathways Shape Autoimmune Disease
A review in Molecular Biology Reports describes how pro-inflammatory forms of regulated cell death, including ferroptosis, pyroptosis and necroptosis, contribute ...
Immune cells in the gut act as an unexpected shield against inflammation
A mouse study finds that IL-2-producing TFH cells sustain regulatory T cells in gut-associated lymphoid tissues, and their loss triggers ...
Gut Microbe Bile Acid Isoallo-LCA Eases Acute Liver Transplant Rejection in Mice via NR4A1/FOXP3 Pathway
A gut microbial bile acid, isoallolithocholic acid, prolonged survival and reduced rejection injury in a mouse liver transplant model by ...
Mouse glioma study links skull marrow immune hubs to tumor control
A mouse study found that organized immune hubs in skull bone marrow respond to nervous-system antigens and influence tumor immunity ...
Review: placental galectins can defend against or enable viruses
A review finds that placental galectins can restrain damaging inflammation or facilitate viral interactions depending on the protein, pathogen, cell ...
Lost Genetic Brakes Push Immune Cells Into an Interferon State Seen in Eczema Patients
Researchers in Tokyo engineered a tracking system for Foxp3-deficient regulatory T cells and found that combined loss of Foxp3 and ...
Aberrant Antibodies That Cripple DNA Repair May Predict Childhood Cancer Years in Advance
Researchers in Norway found that children who later develop cancer carry unusual auto-antibodies against their own DNA repair proteins, suggesting ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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