Early-onset colorectal cancer shows distinct immune-cell spatial patterns
A single-cell spatial analysis found similar overall immune-cell abundance but different local organization of regulatory and helper T-cell populations in ...
Tag: immune microenvironment
METTL1–NSUN1 axis linked to malignant progression and immune features in kidney clear cell carcinoma
A study combining clinical-data analysis, functional cell experiments and single-cell transcriptomics linked the METTL1–NSUN1 axis to malignant progression and immune-microenvironment ...
Eight-gene ENE-related RNA signature stratifies metastasis risk and immune features in nasopharyngeal carcinoma
An RNA sequencing study of 159 nasopharyngeal carcinoma patients found that an eight-gene ENE-related signature predicted distant metastasis risk and ...
Bacteria Hiding Inside Tumors May Shape Epstein-Barr Virus Activity in Nasopharyngeal Cancer
A paired biopsy study finds that nasopharyngeal carcinoma tissue harbors distinct bacterial communities linked to Epstein-Barr virus activity and immune ...
Engineered Exosomes Delivering Curcumin Show Promise Against Phosgene-Induced Lung Injury
A new engineered exosome platform carrying the transcription factor Meis1 and curcumin reduced inflammation, oxidative stress and apoptosis in models ...
Leaking Mitochondrial DNA Emerges as a Central Engine of Cellular Aging
A new review in Biogerontology argues that leaking mitochondrial DNA activates the cGAS-STING innate immune pathway in senescent cells, sustaining ...
Machine Learning Pinpoints Ten-Gene Signature Behind Diabetic Wounds That Refuse to Heal
An integrative study combining transcriptomics, machine learning, single-cell sequencing and mouse validation has identified a ten-gene biomarker panel linked to ...
BK Virus Kidney Infection Shows Broad Immune Disruption in Transplant Patients
A combined transcriptomic and histological study of kidney biopsy tissue reveals widespread immune activation, checkpoint upregulation, and altered T-cell dynamics ...
Plant-Derived Compounds Could Crack Osteosarcoma’s Chemotherapy Resistance by Triggering Ferroptosis
A new review in Molecular Diversity maps how plant-derived natural products can induce iron-dependent ferroptosis and remodel the immune microenvironment ...
Where does the immune pressure go? New framework explains immunotherapy resistance
A new Molecular Cancer review proposes immune-pressure redistribution as a unifying framework explaining why patients resist PD-1/PD-L1 blockade and how ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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