Tag: immune checkpoint blockade

New research shows the immune protein perforin can kill tumor cells on its own by triggering iron-dependent ferroptosis, even when ...

A new narrative review in Frontiers in Oncology details how T cells, macrophages, neutrophils, B cells, NK cells, and dendritic ...

A transcriptomic study links dietary restriction-associated immune and vascular changes in melanoma tumors to better prognosis and improved immunotherapy response.

A new study links tumor-cell RNF128 to reduced CD8-positive T-cell infiltration and poorer immune checkpoint blockade responses in bladder cancer.

A new review details how metabolically reprogrammed cancer-associated fibroblasts build immune-excluded and immunosuppressive tumor niches that undermine checkpoint blockade, and ...

Endothelial ICAM-1 becomes polarized to the tumor periphery as melanomas grow, trapping T cells at the margins, and blocking it ...

A new review argues that glucose, lipid, and amino acid metabolism form one interconnected network driving hepatocellular carcinoma growth, immune ...

In primary undifferentiated pleomorphic sarcoma cell lines, IFN-γ reduced cell counts, increased cell death, and induced CXCR3 ligand secretion in ...

A narrative review finds no support for routine thoracic radiotherapy in chemo-immunotherapy-treated extensive-stage small cell lung cancer and highlights unresolved ...

A 2026 narrative review finds that most myeloid-directed cancer programs show target activity without proving immune conversion and proposes a ...