Zinc Nanovaccine Retrains Immune Cells to Attack Lung Cancer
A mannose-decorated zinc metal-organic framework nanovaccine delivering the tumor antigen CLDN6 reprograms immunosuppressive macrophages in lung tumors into antigen-presenting cells ...
Tag: immune checkpoint blockade
DNA Repair Gene Mutations Predict Dramatically Better Immunotherapy Outcomes in Colorectal Cancer
A study of 450 colorectal cancer patients shows that POLE and POLD1 proofreading gene mutations predict markedly better immunotherapy response ...
Dissolving Hydrogel Gate Breaks the Debye Screening Barrier in Nanochannel Biosensing
A peptide-DNA hydrogel that disassembles on command allows nanochannel biosensors to overcome Debye screening and track lung cancer immunotherapy responses ...
Immune Cell Resident Gene RBPJ Emerges as Key to Lung Cancer Immunotherapy Success
A new single-cell study identifies the transcription factor RBPJ and CD103-positive tissue-resident memory T cells as central drivers of successful ...
Immune Checkpoints on Gamma Delta T Cells Follow Their Own Rules, Study Finds
New research shows that immune checkpoint receptors on human gamma delta T cells are regulated in a lineage- and context-dependent ...
Scientists Map a Hidden Malignant Program in Triple-Negative Breast Cancer
An integrated single-cell and spatial transcriptomic study has identified a triple-negative breast cancer-enriched malignant epithelial program, EP5, linked to aggressive ...
Collagen Receptor CD49b Emerges as Key Switch That Lets Breast Tumors Hide From Immunotherapy
Blocking the collagen receptor integrin alpha-2 (CD49b) on breast cancer cells remodels the tumor immune microenvironment and synergizes with anti-PD-L1 ...
PD-1 and LAG-3 Double-Positive T Cells Predict Better Gastric Cancer Survival
A multicohort study finds that gastric tumors rich in PD-1 and LAG-3 double-positive CD8 T cells—an activated, pre-exhausted population—are linked ...
Ancient Viral Fossils in Tumors Reveal Targets That Drive Anti-Metastatic Immunity in Breast Cancer
New research shows that T cell responses against endogenous retroviral peptides, particularly murine leukemia virus fragments, are critical for checkpoint ...
Scientists Map How Tumours Push Immune Cells Into Exhaustion
A review in Experimental & Molecular Medicine examines how chronic antigen exposure and a hostile tumour microenvironment reprogram T cells ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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