Omicron Reaches Deep Into the Niche: SARS-CoV-2 Engages Stromal Cells and Blood Stem Progenitors
A new PLOS One study shows that the Omicron variant of SARS-CoV-2 engages adipose-derived stromal cells through an NRP1-linked entry ...
Tag: IDO1
Deadly Toxin Rewires Tuberculosis Bacterium to Survive Tryptophan Starvation
A tuberculosis toxin that destroys only the tryptophan transfer RNA tricks the bacterium into boosting amino acid synthesis while preserving ...
IDO1 Inhibitor Plus Melanoma Vaccine Fails to Boost Tumor-Fighting T Cells in Trial
A phase II pilot trial found that the IDO1 inhibitor epacadostat safely reduced kynurenine-to-tryptophan ratios in advanced melanoma patients but ...
Gout Drug Allopurinol Heals Diet-Driven Gut Inflammation Through AhR-IL-22 Pathway
New research shows that the gout drug allopurinol reverses high-fat-diet-induced gut inflammation and barrier dysfunction in mice by restoring tryptophan-derived ...
Why Blocking One Immune Enzyme Fails: Cells Reroute Tryptophan Metabolism
A new review explains why IDO1 inhibitors often fail, revealing that tumors and tissues compensate by rerouting tryptophan metabolism through ...
Researchers reveal how chronic stress drives immune dysfunction in cold tumors
A stress-sensing pathway that helps natural killer cells mature and attack cancer may become a liability when activated continuously, according ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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