High-altitude exposure linked to α-synuclein burden and mouse pathology
A multi-method study linked chronic high-altitude exposure to elevated α-synuclein levels and worse pathology in a mouse model, while human ...
Tag: hypoxia
Review outlines chemotherapy-related fatigue in breast cancer patients at high altitude
A review identifies inflammation and immune readjustment as central factors in chemotherapy-related fatigue among breast cancer patients, while noting that ...
Machine learning and cell study link shikonin to Parkin-dependent activity in hypoxic triple-negative breast cancer
A machine-learning and cell-culture study found that shikonin induced necroptosis and apoptosis in hypoxic MDA-MB-231 breast cancer cells through a ...
Case report of lip protrusions in three trahira found in a drying Brazilian pool
A case-study report of six trahira from Brazilian temporary pools found lip protuberances in three fish from a low-oxygen drying ...
Silent Interferon Signals May Flag Ovarian Tumors That Shrug Off Chemotherapy
A cautious reanalysis of single-cell, TCGA, MRI, and cell-line data links muted type-I interferon signaling and altered cell-state programs to ...
Hypoxia-Driven Mitochondrial Enzyme Helps Pancreatic Cancer Evade Ferroptosis and Resist Gemcitabine
A new study links tumor hypoxia to ferroptosis suppression via SQOR-mediated coenzyme Q reduction, offering a potential strategy to overcome ...
Admission Lactate Adds Little to Prognosis in Severe Traumatic Brain Injury
A two-center study with external validation finds that admission lactate is associated with 30-day mortality after severe traumatic brain injury ...
Rethinking the placenta: why fetal oxygen demand may matter more than maternal symptoms
A new hypothesis proposes that placental sufficiency should be defined by the balance between fetal oxygen demand and system supply, ...
Cancer’s Metabolic Battleground: How Immunometabolism Became Immunotherapy’s Next Frontier
A systematic bibliometric review of more than 3,200 publications reveals that tumor immunometabolism research has surged since 2020, shifting from ...
TRIP13 shields a key metabolic enzyme from destruction, helping colorectal cancer adapt and resist chemotherapy
TRIP13 protects LDHA from FBXW7-mediated degradation, sustaining a lactate-driven antioxidant program that helps colorectal cancer cells adapt to hypoxia and ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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