Where the Bug Lands Decides Which Lung Cells Fight It: Macrophages and Mycobacterium abscessus
New mouse research shows that resident alveolar macrophages are essential for clearing Mycobacterium abscessus from the alveoli but dispensable when ...
Tag: host-directed therapy
Old drugs, new weapons: repurposing therapies against antimicrobial resistance
A comprehensive review maps how approved drugs—from anticancer agents to antidepressants—can be systematically repurposed to combat drug-resistant superbugs.
From AI X-Rays to Ultra-Short Drug Regimens: 2025’s Tuberculosis Breakthroughs
A sweeping 2025 review documents major advances in tuberculosis diagnostics, shorter all-oral drug regimens, novel compounds, vaccines, and disease reclassification, ...
Do Fungal Pathogens Exploit HLA-G-Mediated Immune Tolerance?
The distinction between classical and nonclassical major histocompatibility complex class I molecules helps explain why HLA-G occupies such a unique ...
Onion Extract Boosts Standard Therapy Against Latent Tuberculosis in Rabbit Study
Researchers in Ghana report that an ethanolic extract of pink onion significantly reduced mycobacterial burden and restored immune balance in ...
Malaria drug pipeline review finds promising compounds but few ready for the clinic
A systematic review of 252 studies published between 2024 and 2026 shows natural products dominating antimalarial discovery while warning that ...
Tiny RNA Molecule May Explain Why Some People Resist Tuberculosis Infection
A new PLOS Pathogens study finds that the microRNA-1246 regulates macrophage lipid metabolism and helps explain why some household contacts ...
Plant Flavonoids Emerge as Multi-Target Weapon Against Drug-Resistant Tuberculosis
A new review maps how plant-derived flavonoids attack tuberculosis through multiple molecular mechanisms while outlining the structural features and delivery ...
Old Cancer Drug Candidate Irosustat Shows Promise Against Drug-Resistant Malaria
Researchers report that the steroid sulfatase inhibitor irosustat and its target molecule cholesterol sulfate inhibit drug-resistant Plasmodium falciparum through a ...
Plant Compounds Target Host Immune Signaling to Fight Influenza A Virus
A new review in MicrobiologyOpen details how plant-derived phytochemicals modulate TLR, RIG-I, MAPK, and NF-ÎşB signaling to combat influenza A ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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