Platinum Chemotherapy, Not PARP Inhibitors, Emerges as the Main Driver of Blood Clone Expansion
New research shows carboplatin drives the expansion of TP53-mutant blood clones far more strongly than PARP inhibitors, while inherited homologous ...
Tag: homologous recombination deficiency
Genomic Scars May Predict Which Rectal Cancers Respond to Radioimmunotherapy
A new study finds that homologous recombination deficiency scores show a surprising non-monotonic relationship with pathological response to short-course radiotherapy ...
Turning Cold Tumors Hot: Dual-Target Therapy Offers New Hope for Platinum-Resistant Ovarian Cancer
A new review outlines how combining PARP inhibitors with immune checkpoint inhibitors can convert immunologically cold ovarian tumors into hot ...
Jumping Genes May Ignite Immune Defenses in Stomach Cancers with DNA Repair Weaknesses
New research links LINE-1 retrotransposon overexpression and homologous recombination deficiency in gastric cancer to heightened immune pathway activation and potential ...
Mutational Fingerprints Reveal the Hidden Forces Driving Prostate Cancer
A new Nature study integrates multiple classes of genomic mutations to define the distinct mutational processes that shape prostate cancer ...
Olaparib Benefits HR-Deficient TNBC and Platinum-Sensitive Ovarian Cancers
In a groundbreaking phase 2 clinical trial, researchers have demonstrated the efficacy of olaparib, a PARP inhibitor, in treating metastatic ...
Pan-Cancer Study Reveals DNA Repair Defects
In a groundbreaking study poised to reshape the landscape of precision oncology, researchers have conducted the largest pan-cancer analysis focusing ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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