Stem Cell Enzyme PLA2G7 Emerges as a Driver of Age-Related Memory Decline
Researchers report that suppressing the lipid-metabolizing enzyme PLA2G7 in hippocampal neural stem cells restores inhibitory synapses and improves memory in ...
Tag: hippocampus
Poor Blood Flow to the Brain May Steer Early Tau Pathology Toward Vulnerable Regions
A new mouse study shows that early chronic cerebral hypoperfusion spatially biases tau pathology and drives neuroinflammation at the onset ...
Weekly MRI Reveals Radiation’s Early Fingerprint on the Brain’s Memory Hub
Weekly diffusion MRI during six weeks of partial-brain radiation therapy for high-grade glioma reveals a progressive, dose-dependent increase in hippocampal ...
Diabetes Dementia Breakthrough: Enzyme Blocker Restores Brain Blood Flow and Memory in Rats
Chronic inhibition of the enzyme soluble epoxide hydrolase with TPPU restored memory, cerebral blood flow, blood-brain barrier integrity, and neuronal ...
Resveratrol Shields the Epileptic Brain by Rewiring Ion Channel Genes, Rat Study Finds
A new rat study shows that resveratrol slows epilepsy development and protects the hippocampus by restoring SIRT1 signaling and rebalancing ...
Blocking the Brain’s Cannabis Receptor Repairs Faulty RNA Splicing in Fragile X Mice
A new study in iScience shows that blocking the cannabinoid CB1 receptor with low-dose rimonabant reverses disease-associated alternative splicing defects ...
Autopsy Study Reveals Amyloid Plaques Explain Alzheimer’s Gene Risk But Not Women’s Tau Burden
A landmark autopsy study of 2,550 brains shows APOE-ε4 drives medial temporal tau through amyloid-β while women's tau burden persists ...
Estrogen Receptors May Hold the Key to Anesthesia’s Hidden Effects on the Brain
A new review reveals that the dynamic expression of estrogen receptor subtypes across brain development may explain why anesthesia causes ...
Anesthesia and Surgery Rewire the Alzheimer’s Brain Differently, Mouse Study Suggests
A new exploratory RNA sequencing study finds that the hippocampal response to anesthesia and surgery is directionally inverted in 5xFAD ...
Brain’s Kappa-Opioid Switch: New Map Reveals How Dynorphin Circuits Drive Depression and Anxiety
A new review maps how the kappa-opioid receptor/dynorphin system acts as a circuit-specific switch in the brain's fear and reward ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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