Hippocampal Interneuron Subtypes Show Distinct Tonic Inhibition Plasticity
Brief NMDA receptor activation enhanced tonic GABAergic current density in a subset of non-OLM somatostatin-positive hippocampal interneurons while leaving OLM ...
Tag: hippocampus
Branched-Chain Amino Acid Supplements Partially Ease Hormone Disruption After Brain Injury in Rats
A rat study found that post-injury branched-chain amino acid supplementation partially restored thyroid hormones, vitamin D, calcium, and phosphorus levels ...
Silencing Gasdermin D Shields Hippocampal Neurons in Rat Status Epilepticus
In a lithium-pilocarpine rat model of status epilepticus, hippocampal GSDMD knockdown reduced pyroptosis and ferroptosis markers, improved neuronal survival, and ...
Proximity Labeling Maps the Protein Neighborhoods of Two Amyloid Forms in Alzheimer’s Hippocampus
Proximity labeling in postmortem human hippocampus reveals that pyroglutamate-modified Aβ carries an expanded, variant-specific set of neighboring proteins in Alzheimer's ...
Vagus Nerve Stimulation Boosts Memory in Female Rats Only During Certain Estrous Phases
A single session of vagus nerve stimulation improved memory and hippocampal plasticity in female rats, but only when tested during ...
Microglial NLRP3 Inhibition Restores Memory After Hemorrhagic Shock in Mice
A mouse study finds that inhibiting the NLRP3 inflammasome specifically in microglia reduces hippocampal neuroinflammation and reverses cognitive deficits after ...
Blood Cholesterol Marker Flags Brain Injury Risk in Growth-Restricted Infants
A blood-based cholesterol metabolite, 24S-hydroxycholesterol, shows reduced levels in IUGR infants and predicts neurodevelopmental risk in new mouse and clinical ...
Loss of CD47 Shifts Mouse Hippocampus Toward a Mild Stress-Like State
Single-nucleus RNA sequencing shows that Cd47 loss shifts the mouse hippocampal transcriptome toward a state resembling mild excitotoxic stress.
Apigenin boosts norepinephrine release and brain lactate in aging-model mice
A new mouse and cell study found that the plant flavonoid apigenin improved chemically induced cognitive deficits by activating GPR30 ...
Rab5 Endosomal Overactivation Linked to Oxytocin Receptor Signalling Defects in Early Alzheimer’s Models
A study in young APP/PS1 mice and a Rab5-overactivation model links enlarged early endosomes to mislocalised oxytocin receptors, reduced ERK ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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