Study Maps Focused Transcription Factor Binding in Human Cells
Researchers identified highly focused transcription factor binding sites in human cells, revealing that these narrow regions are essential for maintaining ...
Tag: HepG2 cells
Study Identifies Overlapping Epigenetic Control and Skewed Inactivation at Pig OTC Gene
Researchers have identified a dual-functioning transcriptional regulatory region at the porcine OTC locus that regulates tissue-specific expression while reflecting skewed ...
Metformin Enhances Doxorubicin Activity Against Cultured HepG2 Liver Cancer Cells
A laboratory study demonstrates that combining low-dose metformin with doxorubicin suppresses epithelial-to-mesenchymal transition and enhances antiproliferative effects in HepG2 liver ...
Engineered Carbon Dot Nanozyme Induces Ferroptotic Cell Death in Hepatocellular Carcinoma
Researchers synthesized an ellagic acid-histidine-iron carbon-dot nanozyme that destabilizes iron regulation and depletes antioxidant defenses to induce ferroptosis in human ...
Longer Amiodarone Use Linked to Hepatic Steatosis and Altered Cellular Lipids
A cross-sectional survey analysis linked longer reported amiodarone treatment to higher fatty liver index scores, while cell experiments revealed a ...
Traditional Chinese Medicine Granules Ease Fatty Liver Disease via a Newly Mapped FOXA1-DERL1 Pathway
A new study reports that Huangjing Jiangzhi granules reduce fatty liver disease in mice and liver cells by upregulating FOXA1, ...
AI Framework Mines Traditional Chinese Medicine for Phenotype-Based Drug Discovery
An AI framework combining Kolmogorov–Arnold network drug–target prediction with AutoML modeling of Chinese Materia Medica properties identified lipid-lowering candidates from ...
Solid lipid nanoparticles loaded with oleanolic and asiatic acid show antidiabetic potential in cell studies
Encapsulating oleanolic acid and asiatic acid in solid lipid nanoparticles preserved enzyme inhibition, lowered glucose in liver cell culture medium ...
Oligosaccharides from Thinned Peaches Inhibit α-Glucosidase and Improve Glucose Metabolism in Insulin-Resistant Liver Cells
Researchers purified two oligosaccharide fractions from discarded thinned peaches that strongly inhibit α-glucosidase and restore glucose metabolism in insulin-resistant liver ...
Gene-Edited Red Yeast Ferment Shows Strongest Insulin-Sensitizing Signals in Liver Cells
A gene-edited Monascus strain fermented for 21 days showed the strongest glucose uptake and lipid improvements in insulin-resistant liver cells, ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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