Scientists Map the Earliest Steps of Polycomb Gene Silencing in Human Embryos
A Nature Genetics study shows that the histone mark H2Aub laid down by PRC1 guides the reestablishment of Polycomb repression, ...
Tag: H3K27me3
Metabolic Enzyme NNMT Drives Ovarian Hormone Disorder Through Epigenetic Rewiring
New research in Nature Metabolism reveals that the metabolic enzyme NNMT drives hyperandrogenism in polyendocrine metabolic ovarian syndrome by depleting ...
Plant DNA Viruses Hijack Host Deubiquitinases to Lift Epigenetic Silencing
Cauliflower mosaic virus uses its P6 pathogenicity factor to recruit Arabidopsis deubiquitinases UBP12 and UBP13, which remove repressive histone marks ...
Rival immune messengers turn out to be secret partners in healing
A Nature Communications study shows that the proinflammatory cytokine TNF acts mainly as a costimulator of IL-4-driven gene expression in ...
Epigenetic Drug Valemetostat Shows Dual Action Against HTLV-1 Eye Inflammation
A new study shows that the dual EZH1/2 inhibitor valemetostat counteracts HTLV-1-induced epigenetic changes in retinal cells and suppresses viral ...
Fungal enzyme RTT109 proves essential for inheriting silenced chromatin
A new study in Neurospora crassa shows that the replication-linked histone acetyltransferase RTT109, acting independently of its known product H3K56 ...
Childhood Brain Tumor Study Uncovers KDM2B as a Selective Epigenetic Vulnerability
A comprehensive epigenomic map of medulloblastoma reveals that the chromatin regulator KDM2B sustains the highest-risk tumor subgroups by locking neuronal ...
Metabolic Switch in Heart Cells Rewinds Injury Into Regeneration, Study Finds
New research shows that transient inhibition of the mitochondrial enzyme succinate dehydrogenase triggers coordinated metabolic and epigenetic reprogramming across heart ...
Aging and Rejuvenation Converge on the Same Epigenetic Switch in Mouse Skin
Whole-genome sequencing of mouse skin shows that aging and partial reprogramming converge on PRC2 target genes, where methylation entropy rises ...
Mothers Know Best: Plant Seed Coats Use Epigenetic Switches to Sculpt the Embryo
New research reveals that maternal seed coat tissues in plants use H3K27me3 histone demethylation to control auxin delivery and thereby ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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