Trapping rogue DNA rings in micronuclei could disarm aggressive tumors
An international research team has shown that rings of extrachromosomal DNA lose their cancer-driving activity when trapped in micronuclei, a ...
Tag: genomic instability
Tousled-Like Kinases TLK1 and TLK2 Emerge as Pan-Cancer Drivers of Genomic Instability and Immune Evasion
A pan-cancer analysis of 33 tumor types reveals that the DNA-repair kinases TLK1 and TLK2 drive genomic instability and shape ...
Jumping genes may explain why big dogs age faster and die younger
A large-scale study of 864 dogs finds that giant breeds lose methylation control over LINE1 jumping genes far faster than ...
Genome’s Silent Guardian: HUSH Complex Emerges as Key Player in Cancer
A systematic review in Medical Oncology details how the HUSH complex silences retrotransposons through H3K9me3 deposition and how its dysregulation ...
Smoking May Shorten Colorectal Cancer Survival Most in Tumors With Low LINE-1 Methylation
A prospective cohort study of 1,208 colorectal cancer patients finds that current smoking is linked to substantially worse survival only ...
Hidden DNA Knots: G-Quadruplexes Mapped Across the Complete Human Genome
Using gap-less long-read genome assemblies and 88 diverse human haplotypes, researchers have mapped G-quadruplex DNA structures across the complete human ...
Common Plasticizer Dibutyl Phthalate Damages DNA in Kidney Cells, Study Finds
A new study shows that the common plasticizer dibutyl phthalate causes dose-dependent DNA damage, chromosomal instability, and altered DNA repair ...
Systematic Review Uncovers How ATM Gene Defects Shape Blood Cancers
A new systematic review finds that mutations, methylation, and expression loss of the ATM DNA repair gene are recurrent and ...
Jumping Genes May Ignite Immune Defenses in Stomach Cancers with DNA Repair Weaknesses
New research links LINE-1 retrotransposon overexpression and homologous recombination deficiency in gastric cancer to heightened immune pathway activation and potential ...
How replication stress shapes cancer evolution and opens new doors for therapy
A comprehensive new review explains how replication stress drives cancer genome evolution and why the pathways cells use to survive ...
-
Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
-
University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
-
Bee body mass, pathogens and local climate influence heat tolerance
-
Researchers record first-ever images and data of a shark experiencing a boat strike
-
Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
Embark on a thrilling journey of discovery with Scienmag.com—your ultimate source for cutting-edge breakthroughs. Immerse yourself in a world where curiosity knows no limits and tomorrow’s possibilities become today’s reality!