Mutant Tau Pushes the Cell’s Protein Factory into Overdrive, Study Finds
New research in Translational Psychiatry shows that disease-associated MAPT mutations drive tau accumulation in the nucleolus, hyperactivating ribosomal DNA transcription ...
Tag: frontotemporal dementia
Sleep Disruption Emerges as a Hidden Signature of Temporal Lobe Dementia
A UCL and University of Surrey collaboration has systematically characterised sleep disturbance in the temporal lobe variants of frontotemporal dementia, ...
Brain Waves and Machine Learning Join Forces to Tell Alzheimer’s and FTD Apart
A new explainable machine learning framework combining EEG signals with clinical data distinguishes Alzheimer's disease from frontotemporal dementia with 89.8 ...
Apathy and Personality Changes Drive Early Disability in Frontotemporal Dementia
A large international validation study confirms that apathy, reduced conscientiousness, and frontal lobe shrinkage together explain everyday disability in early-stage ...
Rare Facial-Onset Nerve Disease Reveals Its Brain Footprint in Advanced MRI Study
Advanced MRI has revealed the first consistent brain signature of the ultra-rare neurological disorder FOSMN, showing brainstem atrophy and damage ...
Speech Clocks: How Your Voice May Track the Biology of Aging
A machine-learning speech clock developed by Trinity College Dublin researchers estimates age from voice features and links older-sounding speech to ...
Broken Cellular Recycling Plants Emerge as Common Thread in Neurodegenerative Disease
A new review in Nature Reviews Neurology argues that defective lysosomal function is a central, genetically validated driver of Parkinson ...
Hidden RNA Errors Found at the Synapse in Frontotemporal Dementia
Multi-omic profiling of synaptosomes from C9ORF72-frontotemporal dementia brain and patient-derived neurons reveals widespread synaptic molecular disruption and, for the first ...
Blood Tau Rises in ALS but Tracks Motor Neuron Damage, Not Thinking Skills
A large multicenter study finds that plasma p-tau181, an approved Alzheimer's blood biomarker, is elevated in ALS and rises over ...
Dementia Patients Show Alarming Surge in Compulsive Internet Use, Study Finds
A new case series finds that nearly 23 percent of frontotemporal dementia patients exhibited problematic internet or social media use, ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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