Immune Cell Traps and a Lipid Messenger Drive Scarring in Endometriosis
New research reveals that neutrophil extracellular traps and the lipid messenger sphingosine 1-phosphate form a self-amplifying feedback loop that drives ...
Tag: fibrosis
Hedgehog-Responsive Perivascular Cells Emerge as Master Switches of Blood Vessel Repair and Disease
A new review synthesizes a decade of evidence showing that GLI1-positive perivascular cells act as state-dependent regulators of angiogenesis, capable ...
Feverfew Compound Parthenolide Eases Skin Fibrosis by Stabilizing Mitochondria-ER Contacts
A new study shows that parthenolide, a compound from feverfew, alleviates cellular senescence and skin fibrosis in localized scleroderma by ...
Aging Muscle Fails Through Broken Cell-to-Cell Communication, Review Finds
A new review in Aging Cell argues that skeletal muscle aging is driven by the breakdown of multicellular communication networks ...
Plant Compounds Show Promise in Taming Radiation-Induced Fibrosis Through TGF-β Control
A new review details how plant-derived compounds such as curcumin, resveratrol, and EGCG modulate TGF-β signaling to potentially limit radiation-induced ...
Single-Cell Atlas Reveals Macrophages That May Drive Chronic Kidney Transplant Rejection
A single-cell multi-omic study of transplanted mouse kidneys identifies SPP1-positive macrophages and a CEBPβ-centered regulatory program as candidate drivers of ...
Epigenetic Enzymes Emerge as Promising Drug Targets for Endometriosis
A new review in Reproductive Sciences details how dysregulated histone deacetylases drive endometriosis and how existing and experimental HDAC inhibitors ...
First-in-Human PET Tracer Tracks Active Fibrosis With Safe Radiation Dose
A first-in-human study shows the PDGFRβ-targeting PET tracer Ga-ATH001 delivers a safe radiation dose and highlights active liver fibrosis in ...
Early Oxygen-Boosting Enzyme Therapy Shows Promise Against Tuberculous Granulomas in Mice
A new study in BMC Infectious Diseases shows that early local catalase therapy relieves hypoxia, restores vascular health, and corrects ...
Autophagy’s Double-Edged Role in Womb Scarring and Age-Related Fertility Decline
A new review in Reproductive Sciences argues that autophagy, the cell's recycling machinery, plays a context-dependent dual role in endometrial ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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