Diseased Blood Vessels May Drive Fibrosis Across Multiple Organs
A new review argues that dysfunctional blood vessels, through failed endothelial quiescence, abnormal remodeling modes and disrupted angiocrine signaling, may ...
Tag: fibrosis
Beyond Calcium: Imaging Reveals the Hidden Fibrotic Side of Aortic Valve Disease
A new review argues that calcific aortic valve disease is two diseases in one, and that imaging of both fibrous ...
Antibody pamrevlumab blocks fibrotic drivers of lens clouding in pediatric cells
In a laboratory study of primary pediatric lens epithelial cells, the anti-CTGF antibody pamrevlumab suppressed collagen production, migration and proliferation ...
Scientists pinpoint THBS1 as a driver of fat tissue scarring in obesity and diabetes
A single-nucleus atlas of human visceral fat identifies THBS1-expressing stem cells and adipocytes as drivers of fibro-inflammatory remodeling in obesity ...
Single-cell map reveals immune-fibrotic imbalance driving COPD
A single-cell RNA sequencing analysis of 101,009 cells identifies 17 cell subtypes and reveals reduced macrophage and fibroblast signaling alongside ...
Bayesian Model Ties Liver Follow-Up Intensity to Patient Adherence
A Bayesian decision model suggests MASLD follow-up intensity should be calibrated to patient adherence, with aggressive monitoring favored for lifestyle-modification ...
Lactate Signal H3K18 Lactylation Shows Dual Roles in Human Disease
A new review maps how the histone lactylation mark H3K18la links lactate metabolism to gene control, driving both disease progression ...
MicroRNA Scars of Heart Failure Persist After LVAD Support in Ischemic Cardiomyopathy
A paired tissue study of 11 patients finds that microRNA patterns tied to apoptosis and fibrosis remain largely unchanged after ...
Disulfiram Shows Kidney-Protective Effects Against Paraquat Poisoning in Rat Study
In a rat model of paraquat-induced kidney damage, the approved drug disulfiram reduced tissue injury, fibrosis, and oxidative stress, with ...
Spatial gene map reveals compartment-specific reprogramming in inflamed fatty livers
A spatial transcriptomics study of 16 MASH patients and eight controls maps compartment-specific CYP450 suppression, immune activation, and disrupted cell-cell ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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