New Therapies Reshape Treatment of Rare Childhood Skin Sclerosis
A new narrative review maps how methotrexate, biologics, and JAK inhibitors are transforming the management of pediatric morphea, a rare ...
Tag: fibrosis
Metabolic Switch in Heart Cells Rewinds Injury Into Regeneration, Study Finds
New research shows that transient inhibition of the mitochondrial enzyme succinate dehydrogenase triggers coordinated metabolic and epigenetic reprogramming across heart ...
Male mice fare worse after heart radiation, revealing sex differences in cardiac injury
A Mayo Clinic study of irradiated mice shows that males develop inflammatory dilated cardiomyopathy and fibrosis after cardiac radiation while ...
Vaccination shields the immune system from lasting damage after viral infection
A mouse study led by Pompeu Fabra University shows that recovering from an acute viral infection leaves lasting splenic damage ...
Omega-3-derived lipid Resolvin E1 rejuvenates aged muscle healing by resolving inflammation
New research in GeroScience shows that the omega-3-derived lipid mediator Resolvin E1 accelerates inflammation resolution and boosts muscle stem cell ...
Transplant Drug Rewires Prostate Tissue in Two Distinct Phases, Rat Study Finds
A new rat study shows the immunosuppressant mycophenolate mofetil dismantles prostate stromal fibers in two timed phases, reshaping collagen, immune ...
Cholesterol Drug Alirocumab Shields the Heart From Alcohol Damage in Rat Study
A new GeroScience study shows that weekly alirocumab, an approved PCSK9 inhibitor, protected rats from alcohol-induced cardiac dysfunction, fibrosis, and ...
Fibrosis Marker HE4 Predicts Death and Heart Attacks a Decade Out in Coronary Patients
A new ten-year study of nearly 400 angiographically confirmed coronary artery disease patients shows that the profibrotic protein HE4 independently ...
Engineered Macrophages Emerge as a New Frontier in Cell Therapy for Solid Tumors
A new review details how chimeric antigen receptor-engineered macrophages are overcoming the barriers that stalled CAR-T therapy in solid tumors, ...
Endurance Exercise Reshapes the Liver in Males and Females Through Distinct Molecular Routes
New research from the University of Missouri shows that endurance exercise improves liver health in both sexes but rewires the ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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