Hidden Switch Lets Melanoma Cells Flip Into Metastasis Mode, Study Finds
Researchers in Milan have identified MyD88 as a tumor cell-intrinsic switch that sustains a metastasis-competent, integrin-driven cell state in NRAS-mutant ...
Tag: extracellular matrix
Fluorescent Tagging Toolkit Illuminates the Hidden Architecture of the Worm Cuticle
Researchers built 105 fluorescently tagged extracellular matrix proteins in C. elegans, creating a standardized atlas that reveals how the collagen-rich ...
Disc Degeneration Traced to a Histone Switch That Silences the Cell’s Mitochondrial Cleanup Crew
A new study shows that the chromatin protein CBX3 accelerates disc degeneration by silencing the SESN2 gene through H3K9me3 marks, ...
Scientists Uncover Hidden Protein Driver Behind Scarring Kidney Disease
New research reveals that the protein Annexin A1 drives kidney fibrosis by activating YAP signaling and suppressing autophagy in renal ...
Enzyme Autotaxin Drives Scarring in the Optic Nerve’s Load-Bearing Scaffold in Glaucoma
Researchers in Dublin report that the enzyme autotaxin and its lipid product lysophosphatidic acid drive fibrosis in lamina cribrosa cells ...
One Gene, Two Proteins: Why CFH Cancer Biomarker Studies May Be Measuring the Wrong Molecule
A new commentary in BMC Cancer warns that pan-cancer studies treating CFH as a single cancer biomarker have been measuring ...
Collagen Scaffold in Tumors Primes Colorectal Cancer Cells to Evade Chemotherapy
Patient-derived organoid and xenograft models reveal that a collagen I-rich tumor matrix activates TGFβ signaling and LTBP2 expression, priming colorectal ...
Hidden Fibroblast State at the Pancreatic Tumor Frontier Predicts Poor Survival and Points to Existing Drugs
Integrating single-cell and spatial transcriptomics, researchers identified a novel invasive-frontier fibroblast state and the multicellular community it defines, which independently ...
Collagen Clue: How COL6A1 May Drive Bile Duct Cancer’s Deadly Spread
A new review in Cancer Reports proposes that the extracellular matrix protein COL6A1, overexpressed in the fibrotic stroma of cholangiocarcinoma, ...
How a Pathogen Hijacks Nerve Signals to Break Down a Worm’s Skin
Researchers discovered that the bacterium Pseudomonas aeruginosa exploits neuronal signaling in C. elegans to impair lysosomal function and disrupt collagen ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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