Blocking EP300 Rewires Scar-Associated Macrophages to Fight Acute Liver Failure
A new Nature Communications study shows that inhibiting the epigenetic enzyme EP300 restores the antibacterial function of scar-associated macrophages by ...
Tag: epigenetics
Diseased Kidneys Age Faster at the Cellular Level, Single-Cell Epigenome Atlas Reveals
A cross-species single-cell epigenome atlas shows that kidney disease accelerates epigenetic aging most dramatically in tubular epithelial cells, which lose ...
Common Antibiotic Calms Children’s Wheezing by Rewriting Inflammatory Memory in Lung Immune Cells
A new study shows azithromycin eases post-inflammatory wheezing in children by inhibiting SETD1B-driven H3K4me3 methylation and rebalancing macrophage polarization in ...
Genes and Epigenetics Converge to Explain Sudden Cardiac Death Without Family History
A new review maps how common genetic variants, insertion/deletion polymorphisms, microRNAs, DNA methylation and histone modifications together shape the risk ...
NIH Backs Bold Epigenetics Quest to Decode How Immune Cells Walk the Tightrope Between Defense and Disease
Van Andel Institute's Dr. Derek Janssens has received a nearly $4.6 million NIH New Innovator Award to develop tools that ...
First Mosaic Case Rewrites the Genetic Story of a Rare Overgrowth Syndrome
Researchers report the first known case of Cohen–Gibson syndrome caused by a mosaic EED variant, expanding the mutational spectrum of ...
Hidden DNA Rings and a Rogue Gene Reveal Ovarian Cancer’s Adaptive Defense
A new study links HDAC inhibitor treatment to remodeling of extrachromosomal circular DNA in ovarian cancer and identifies LMO2 as ...
Cancer Cells Rewire Immune Neutrophils Through a Fumarate-Driven Metabolic Switch, Study Finds
A new Nature Cancer study reveals that the kinase GSK3β in colorectal tumor cells drives fumarate accumulation that epigenetically reprograms ...
Crushing Rice Seeds Under Pressure Leaves Genetic Scars That Last Nine Generations
A rice lineage derived from seeds treated with 100 megapascals of hydrostatic pressure still shows reduced height, tiller number, and ...
Loss of Tet2 Rewires the Aging Bone Marrow to Drive Blood Cancers, Mouse Study Shows
A new conditional knockout mouse model shows that loss of the epigenetic regulator Tet2, combined with aging and a reshaped ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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