The Methylation Test That Decides Brain Cancer Treatment Faces a Reckoning
A new Mayo Clinic review in the Journal of Neuro-Oncology examines how MGMT promoter methylation guides brain tumor treatment, why ...
Tag: epigenetics
How Early-Life Exposures Leave Lasting Marks on the Preterm Lung
A new narrative review in Pediatric Research reframes bronchopulmonary dysplasia as a disorder of epigenetic programming in which hyperoxia, inflammation ...
Chemical Tags on Brain DNA Reveal How Alzheimer’s Risk Genes Do Their Damage
A large postmortem study identified 107 brain DNA methylation sites linked to Alzheimer's pathology and showed that methylation partially mediates ...
Diabetes and Cancer Feed Each Other: How Epigenetics Explains the Deadly Two-Way Street
A comprehensive review in Diabetes Therapy maps the bidirectional relationship between diabetes and cancer, positioning epigenetic dysregulation as the molecular ...
Gene Silencing by Methylation May Explain Why Breast Cancer Cells Dodge TRAIL Therapy
A new review in Molecular Biology Reports argues that DNA methylation silencing of the TRAIL pathway components DR5, DcR2, and ...
Rethinking Brain Health: How Early Life Shapes the Brain Across a Lifetime
A new expert review in Translational Psychiatry proposes a developmental brain health framework that reframes mental health as lifespan regulatory ...
Heart Cell Metabolism Switch Reactivates Dormant Repair After Heart Attack
Researchers at Sanford Burnham Prebys report that temporarily blocking the metabolic enzyme succinate dehydrogenase triggers an epigenetic switch in mouse ...
Chromatin Loss Rewires Kidney Cancer Mitochondria, and an Old Drug Can Reverse It
A Nature Communications study shows that loss of the SWI/SNF subunit SMARCD1 drives clear cell renal cell carcinoma through a ...
Lactate Marks on Histones Drive Wilms Tumor Growth Through a Self-Reinforcing Genetic Loop
New research reveals that lactate-driven histone H3K18 lactylation activates a PSRC1/AKT/HIF-1α positive feedback loop that propels the malignant progression of ...
Jonathan the 194-Year-Old Tortoise Reveals a Genetic Secret to Aging Slowly
A Vanderbilt-led team sequencing the genome and epigenome of Jonathan, a 194-year-old giant tortoise on St. Helena, found that promoters ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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