Body Clock, Gut Microbes and DNA Methylation Converge in Depression Study
A pilot multi-omics study links disrupted sleep timing, specific gut microbial signatures, and altered DNA methylation at neural-related genes in ...
Tag: epigenetics
Fungal wilt pathogen’s epigenetic toolkit mapped in first genome-wide HDAC survey
A genome-wide study has identified 11 histone deacetylase genes in Fusarium oxysporum, revealing how the devastating wilt pathogen uses epigenetic ...
Blood-based DNA methylation patterns track breast cancer response to chemotherapy
A new study links methylation changes in the KDM5 gene family and cofactors, measured in blood before and after neoadjuvant ...
Givinostat blocks colorectal cancer growth by silencing ADAM12 through miR-1938
New research shows the HDAC inhibitor givinostat stalls colorectal cancer growth by upregulating miR-1938 to suppress ADAM12, with no systemic ...
How a high-fat diet may help colon cancer spread to the liver
MIT biologists have identified a YAP1-driven regenerative pathway, activated by diet-derived ceramides, that colorectal cancer cells hijack to metastasize to ...
Lactate-Driven Epigenetic Shifts Reshape Liver Cancer Immunity
New research reveals that lactate-driven histone lactylation promotes Treg/Th17 imbalance in liver cancer via the PTPRM-STAT3 axis.
Two-Drug Combination Locks HIV Transcription into Durable Silence
A new iScience study shows that combining a selective CDK9 inhibitor with a PP2A-activating drug durably silences HIV transcription in ...
Climate-Ready Seaweeds: Pangenomics and Multi-Omics Could Rescue Kelp Forests
A new review outlines how pangenomics, seascape genomics, and multi-omics can be integrated into a single pipeline to breed climate-resilient ...
Dietary supplement Ca-αKG slows lung tumors in female mice but speeds growth in males, UCLA study finds
A UCLA study found that the dietary supplement calcium alpha-ketoglutarate slowed lung tumor growth in female mice while enlarging tumors ...
Eye Cancer’s Hidden Weakness: CRISPR Screens Expose p300 as a Lifeline for GNAQ-Mutant Tumors
CRISPR-based synthetic lethal screening has identified the acetyltransferases p300 and CBP as essential chromatin partners for YAP-driven transcription in GNAQ-mutant ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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