Persister cells hiding in minimal residual disease drive cancer relapse
A new review outlines how drug-tolerant persister cells hidden within minimal residual disease drive cancer relapse and how pathway inhibitors, ...
Tag: epigenetic reprogramming
Maternal high-fat diet before pregnancy may program offspring heart disease risk
A new review synthesizes evidence that maternal high-fat diet before and during pregnancy may program offspring coronary artery disease risk ...
Rewriting the First Genome: How Zygotic Activation and Epigenome Reprogramming Shape Early Life
A new research topic in Frontiers in Cell and Developmental Biology brings together studies on zygotic genome activation, epigenetic reprogramming, ...
Innate Immune Memory: How Epigenetic and Metabolic Rewiring Shapes Health and Disease
A new review in the Journal of Molecular Medicine explains how trained immunity, driven by epigenetic and metabolic reprogramming of ...
Melanoma’s Deadly Shift: DNA Methylation Rewrites the Tumor as It Spreads
A paired-sample study of 38 melanoma patients reveals that metastases undergo coordinated DNA methylation reprogramming largely independent of driver mutations, ...
Snail2 Emerges as the Master Switch Behind Partial EMT, Metastasis and Development
A comprehensive review in Cell Death Discovery maps how the transcription factor Snail2 governs partial epithelial-mesenchymal transition, driving both embryonic ...
How Shapeshifting Tumor Cells Outsmart Cancer Treatment
A new review explains how tumor cells reversibly switch identities through epigenetic and microenvironmental programs, driving metastasis and therapy resistance.
MUC1: The Sticky Protein That Turns Guardian of Epithelia Into Engine of Cancer
A sweeping new review maps how the epithelial guardian protein MUC1, and especially its MUC1-C signaling subunit, is hijacked by ...
Circular DNA Emerges as an Epigenetic Engine Driving Cancer’s Rapid Adaptation
A new review in Molecular Cancer argues that extrachromosomal DNA acts as a dynamic epigenetic reprogramming platform that reshapes chromatin, ...
Shifting Identities: How Lung Cancer Cells Change Face to Outsmart Treatment
A new review explains how small-cell lung cancer cells exploit lineage infidelity to switch molecular identities under therapy, and how ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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