New Wee1 function explains toxic side effects of cancer drugs
Researchers have discovered a previously unknown early cell cycle function of Wee1 that may explain the toxic side effects of ...
Tag: drug target
Deep Learning Model Accelerates Drug Target Screening and Repurposing Opportunities
Researchers have developed a deep learning architecture combining transformers and convolutional neural networks to predict drug-target affinities and accelerate virtual ...
Endothelial TXNIP emerges as a driver of pulmonary vascular remodeling
A new study reports that inhibiting the protein TXNIP in pulmonary vascular endothelial cells attenuates pulmonary hypertension and vascular remodeling ...
Ovarian Cancer Cells Depend on USP15 Enzyme, Offering a Sharper Therapeutic Target
UMBC researchers found that ovarian cancer cells depend heavily on the enzyme USP15, and reducing it slows tumor growth, disrupts ...
Cell-Free Assay Cracks Open the Malaria Parasite’s Egress Machinery and Yields a Potent New Inhibitor
Researchers have reconstituted the malaria parasite's SERA6 egress protease maturation pathway in a cell-free assay, proving the mature enzyme is ...
Water’s Hidden Shape Reveals the Trigger Point That Spreads Dementia Proteins
Northwestern University researchers have identified a single water-defined hotspot on tau proteins that drives the misfolding cascade behind Alzheimer's and ...
Experimental Antibody-Drug Conjugate Shrinks Brain Metastasis in Rare Salivary Gland Cancer
A case report describes a durable 54.5 percent shrinkage of a dural-based brain metastasis in a patient with HER2-negative salivary ...
Tilfrinib Blocks PTK6 to Curb Ovarian Cancer Cell Growth and Spread
A new study shows that inhibiting the kinase PTK6 with the drug tilfrinib suppresses the proliferation and migration of ovarian ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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