Leukemia drug Ponatinib shrinks hypertrophic heart cells in early lab test
A new study combining network pharmacology, molecular docking, and H9C2 cell experiments found that low-dose Ponatinib significantly reduced high-salt-induced hypertrophy ...
Tag: drug repurposing
Rheumatism drug teriflunomide shows subtype-dependent effects in breast cancer cells
A cell study finds teriflunomide suppresses growth signalling in luminal breast cancer cells while triple-negative cells show adaptive kinase rewiring.
Antimalarial Drugs Linked to Longer Life in Huge Health-Record Study
A large observational study in Israeli and US health records found that exposure to the antimalarial drugs atovaquone-proguanil and mefloquine, ...
Why repurposed drugs failed against COVID-19: evidence, policy and the Bulgarian case
A systematic review and meta-analysis confirms that hydroxychloroquine, chloroquine, ivermectin, azithromycin and doxycycline lack clinically meaningful efficacy against COVID-19, and ...
Research report: Repurposing the phospholipase A2 inhibitor, darapladib, to combat multidrug-resistant fungal pathogens, including Candida auris
A screen of about 2,600 approved drugs identified the phospholipase A2 inhibitor darapladib as a potent, resistance-resistant antifungal candidate against ...
Plasma Protein Signatures Predict Rheumatoid Arthritis Years Before Symptoms Appear
A UK Biobank study of 47,537 people identified 213 plasma proteins linked to rheumatoid arthritis onset and built a deep ...
Nilotinib targets NEIL3 to restore anoikis in liver cancer cells
A new study reports that the approved leukemia drug nilotinib binds the DNA repair protein NEIL3 to block fatty acid ...
SGLT2 inhibitor oncology research expands as clinical proof remains uneven
A 346-publication analysis finds rapidly expanding research on SGLT2 inhibitors across cancer safety, antitumor mechanisms, real-world outcomes and cardio-oncology, but ...
Disulfiram Shows Kidney-Protective Effects Against Paraquat Poisoning in Rat Study
In a rat model of paraquat-induced kidney damage, the approved drug disulfiram reduced tissue injury, fibrosis, and oxidative stress, with ...
AI map of bowel tumours reveals drug vulnerabilities in hardest-to-treat colorectal cancer
An international team led by RCSI and The Institute of Cancer Research, London, used an AI tool called iPhenMap to ...
-
Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
-
University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
-
Bee body mass, pathogens and local climate influence heat tolerance
-
Researchers record first-ever images and data of a shark experiencing a boat strike
-
Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
Embark on a thrilling journey of discovery with Scienmag.com—your ultimate source for cutting-edge breakthroughs. Immerse yourself in a world where curiosity knows no limits and tomorrow’s possibilities become today’s reality!