Tag: drug repurposing

A two-decade bibliometric analysis of nearly 5,000 studies maps how small molecule drug research transformed lung cancer therapy, revealing China's ...

A randomized crossover trial found that four weeks of sildenafil or tadalafil reduced pro-inflammatory lipid mediators in the blood and ...

A deep-learning-guided virtual screen identified four molecules that block the HIF-1α/VHL interaction, including the approved myeloma drug ixazomib, which protected ...

A new study shows that the fluorouracil derivative carmofur kills aggressive ovarian cancer cells and blocks their migration by disrupting ...

A new study built 49 transcriptomic aging clocks across human tissues and mapped how thousands of drugs show structured but ...

A leakage-aware, auditable computational framework trained on LINCS L1000 signatures identifies class I HDAC inhibitors, led by Mocetinostat, as top ...

Researchers repurposed the approved drugs talazoparib, tivozanib and isradipine as candidate inhibitors of VAV2 signaling that reduced oxidized LDL uptake ...

Researchers used virtual drug repurposing to identify FDA-approved antibiotics Carbenicillin and Ceforanide as inhibitors of the β-catenin/Tcf4 interaction, showing anti-proliferative ...

A Swedish randomised crossover trial found that six months of oral salbutamol significantly improved motor function, muscle strength and respiratory ...

A network-based study finds that the antiparasitic drug praziquantel alleviates liver fibrosis by targeting the estrogen receptor gene ESR1 in ...