Bioinformatics pipelines race to outsmart multidrug-resistant tuberculosis
A new review maps how machine learning, molecular docking and subtractive genomics are being combined to explain drug resistance in ...
Tag: drug repurposing
Vinpocetine Eases Lung Inflammation in Mice by Damping Pentraxin 3
A mouse study of mixed granulocytic asthma suggests the drug vinpocetine reduces airway inflammation by lowering levels of the immune ...
Drug Repurposing Candidate Ebselen Boosts Mitochondrial Function Across Disease Models
A preclinical study reports that the organoselenium compound ebselen improved mitochondrial respiration, ATP production and exercise capacity in yeast, human ...
Osimertinib and Selinexor Team Up Against Aggressive T-Cell Leukemia in Preclinical Study
A preclinical study reports that the EGFR inhibitor osimertinib and the XPO1 inhibitor selinexor synergistically deplete c-MYC and trigger nucleolar ...
Research report: Integrated chemical profiling and lipidomics reveal that Mailuoning oral liquid alleviates diet-induced MASLD via PPARα-mediated lipid homeostasis and COX-2 inhibition, with identification of potential active constituents
A traditional Chinese medicine formula that has been used clinically in China for over three decades has now been studied ...
Approved Drugs Dissolve Mutant Polymerase Aggregates and Restore Motor Function in Mice
Two already approved drugs, diltiazem and sulbactam, dissolved mutant POLGA aggregates and restored mitochondrial DNA replication and motor function in ...
Four-Qubit Quantum Layer Shows Hints of Efficiency in Drug-Target Prediction
A hybrid quantum-classical graph neural network preserved ranking information under extreme compression on a kinase benchmark, but multi-seed testing shows ...
Research report: Ambrisentan ameliorates methotrexate nephrotoxicity through modulation of RhoA/ROCK and PI3K/MDM2-associated signaling: network pharmacology-guided discovery and in vivo confirmation
A rat study found that the pulmonary hypertension drug ambrisentan, given before and during methotrexate exposure, protected the kidneys by ...
Desipramine Blocks Neuronal Ferroptosis in Ischemic Stroke Mouse Model
A new mouse and cell study shows that inhibiting acid sphingomyelinase with desipramine lowers ceramide, curbs neuronal ferroptosis and reduces ...
Patent Data Added to a Drug Repurposing Knowledge Graph Failed to Beat Simpler Baselines for Duchenne Muscular Dystrophy
A time-sliced evaluation found that adding patent-derived relations to a Duchenne muscular dystrophy knowledge graph perturbed rankings without establishing uniform ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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