Tag: drug repurposing

A leakage-aware, auditable computational framework trained on LINCS L1000 signatures identifies class I HDAC inhibitors, led by Mocetinostat, as top ...

Researchers repurposed the approved drugs talazoparib, tivozanib and isradipine as candidate inhibitors of VAV2 signaling that reduced oxidized LDL uptake ...

Researchers used virtual drug repurposing to identify FDA-approved antibiotics Carbenicillin and Ceforanide as inhibitors of the β-catenin/Tcf4 interaction, showing anti-proliferative ...

A Swedish randomised crossover trial found that six months of oral salbutamol significantly improved motor function, muscle strength and respiratory ...

A network-based study finds that the antiparasitic drug praziquantel alleviates liver fibrosis by targeting the estrogen receptor gene ESR1 in ...

A new review argues that lipid metabolic reprogramming acts as a convergence node for treatment resistance in aggressive non-Hodgkin lymphoma, ...

Genomic analysis of nearly 2,000 dogs reveals that they carry the same cereblon variation that makes mice insensitive to thalidomide, ...

Researchers report that the osteoarthritis drug diacerein kills glioma cells by triggering caspase-3 and GSDME-mediated pyroptosis, revealing a new drug-repurposing ...

A major new review finds that symptomatic therapies for Alzheimer disease, from cholinesterase inhibitors to personalized psychosocial care, deliver meaningful ...

Egyptian researchers found that the alcohol-aversion drug disulfiram synergizes with fluconazole, downregulates the Cdr1 efflux pump, and inhibits biofilm formation ...