Human Enzymes Found to Deactivate Promising Tuberculosis Drug Macozinone
Researchers have identified the human enzymes PTGR1 and PTGR2 as the cause of an unprecedented metabolic inactivation of the antitubercular ...
Tag: drug metabolism
Gut Microbes May Decide Whether Your Medicine Works or Harms You
A new review explains how gut microbial enzymes, bioaccumulation, and enterohepatic recycling can activate, inactivate, or toxify drugs, while cautioning ...
Jatropha curcas Leaf Extracts Inhibit Key Drug-Metabolizing Enzymes in Rat Liver Microsomes
A new in vitro study reports that aqueous and ethanol leaf extracts of Jatropha curcas moderately inhibit the drug-metabolizing enzymes ...
High Altitude Reshapes Diabetes Drug Dapagliflozin in Rats, With Effects Fading Over Time
A controlled rat study found that simulated 6,000-meter hypoxia raised dapagliflozin exposure 6.58-fold after acute exposure and 2.11-fold after chronic ...
Research report: Estimating metabolic pathway overlap in precision oncology: integrating pharmacogenetics and polypharmacy
Only a small fraction of the drugs recommended for gastrointestinal cancers are directly steered by known pharmacogenetic variants, yet the ...
Large Language Models Could Help Detect Pharmacogenomic Phenoconversion
A 2026 perspective proposes that large language models could integrate genetic and clinical records to identify possible pharmacogenomic phenoconversion, while ...
Walnut Compound Juglone Blocks Key Drug-Metabolizing Enzyme CYP2C9 in Lab Study
In vitro experiments show juglone, a naphthoquinone from walnut green husks, potently and competitively inhibits the human drug-metabolizing enzyme CYP2C9, ...
How Menopause Reshapes Gut Microbes That Influence How Drugs Work
A new review argues that menopause-driven gut microbiome changes may reshape drug metabolism and explain variability in medication response among ...
When Cytochrome P450 Inhibition Becomes a Drug Designer’s Best Friend
A new review argues that cytochrome P450 inhibition, long treated as a drug-discovery liability, can be a powerful therapeutic strategy ...
Worms Carry a Hidden Defense Against a Troubling Class of Drugs
New research reveals that the nematode Caenorhabditis elegans deploys a dedicated genetic defense system against cationic amphiphilic drugs, a finding ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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