AI Steps Into RNA Drug Discovery, From Small Molecules to Oligonucleotide Therapeutics
A new review maps how artificial intelligence is transforming RNA-targeted drug discovery across both small molecules and oligonucleotide therapeutics.
Tag: drug design
Alzheimer’s Drug Failure Gets a Second Life: Failed Simufilam Scaffold Reborn as PTP1B Inhibitor
Researchers redesigned 52 derivatives of the failed Alzheimer's drug simufilam to target PTP1B, a key enzyme in neuroinflammation, with lead ...
Computational Design Points to New Indolinone Drug Candidates Against Cancer
Researchers have computationally designed ten novel indolinone-based anticancer candidates and prioritized two, Pred 9 and Pred 10, as potential MEK1 ...
Indanone Compounds Show Promise Against Parkinson’s and Alzheimer’s in Animal Studies
Indian researchers have synthesized arylidene indanone derivatives that restore motor function in Parkinson's model mice and memory in Alzheimer's model ...
Buckwheat Compound Fagopyrine Emerges as Computational Lead for AKT1 Cancer Drug Design
A pan-cancer computational study identified the buckwheat-derived compound fagopyrine as a strong predicted binder to the AKT1 kinase, positioning it ...
AI-Designed PET Probe Reaches First Human Test for Imaging PARP-1 in Cancer
An AI-assisted design pipeline produced the gallium-68 PET tracer Ga-DOTA-FZPF, which targets PARP-1 and has now completed a first-in-human evaluation ...
Nitrofuran-Tweaked Ciprofloxacin Analogues Show Potent Activity Against Resistant Staphylococcus aureus
Chemists have fused nitrofuran groups onto ciprofloxacin to create hybrid antibiotics up to sixteen times more potent than the original ...
Trojan Horse Inhibitors Slip Through Gasdermin Pores to Shut Down Pyroptosis
New research shows that gasdermin D pores formed during pyroptosis can admit selectively designed caspase inhibitors, allowing the inflammatory cell ...
Zinc Complexes Emerge as Safer Rivals to Platinum Cancer Drugs, Landmark Review Finds
A systematic review of 66 zinc(II) Schiff base complexes shows that octahedral geometry and red-shifted imine infrared signatures predict potent, ...
Designed Protein Blocks Inflammation Receptor at Its Membrane Core
Scripps Research scientists used computer-aided protein design to create a synthetic transmembrane protein that binds TLR4 inside the cell membrane ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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