DNA hydroxymethylation shifts in the striatum tracked across stages in a Parkinson’s mouse model
In a 6-OHDA mouse model of Parkinson's disease, striatal 5hmC levels and linked synaptic gene programs changed dynamically at two ...
Tag: dopaminergic neuron loss
Rotenone-induced Parkinsonism in mice reverses within a year
A 12-month longitudinal study finds that Parkinson-like motor deficits and dopaminergic pathology caused by chronic rotenone exposure in mice fully ...
High-altitude exposure linked to α-synuclein burden and mouse pathology
A multi-method study linked chronic high-altitude exposure to elevated α-synuclein levels and worse pathology in a mouse model, while human ...
Human GLUD2 Gene Variant Worsens Parkinson’s Disease by Igniting an Astrocyte–Microglia Complement Cascade
A human-specific GLUD2 gene variant worsens Parkinson's disease pathology in mice by driving complement C3 signaling from astrocytes to microglia, ...
Introducing PIGMO: Novel Pigmented Mouse Model for Parkinson’s
In a remarkable leap forward for Parkinson’s disease research, scientists have introduced a groundbreaking animal model that could redefine the ...
Neurotrophic Peptide Therapy Advances Parkinson’s Treatment
In a pioneering advance that could redefine therapeutic strategies for neurodegenerative disorders, a team of researchers led by Krasnienkov, D., ...
Super-Resolution Ultrasound Reveals Brain Issues in Parkinson’s
In a groundbreaking study set to redefine our understanding of Parkinson’s disease, researchers have employed cutting-edge super-resolution ultrasound imaging to ...
Parkinson’s Alters Brain DNA Methylation Patterns
In a groundbreaking study set to reshape our understanding of Parkinson’s disease (PD), researchers have unveiled critical epigenetic modifications in ...
LRRK2 Mutation Causes Neurodegeneration via Microglial Inflammation
A newly identified mutation in the LRRK2 gene, known as P1446L, has been found to drive the degeneration of dopaminergic ...
Stigmasterol Activates Nrf2 Pathway, Boosts Antioxidants in Parkinson’s
In the ever-evolving field of neurobiology, one of the notable breakthroughs is the discovery of the antioxidant properties of stigmasterol, ...
-
Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
-
University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
-
Bee body mass, pathogens and local climate influence heat tolerance
-
Researchers record first-ever images and data of a shark experiencing a boat strike
-
Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
Embark on a thrilling journey of discovery with Scienmag.com—your ultimate source for cutting-edge breakthroughs. Immerse yourself in a world where curiosity knows no limits and tomorrow’s possibilities become today’s reality!