DNA Repair Enzymes RecA and UvrD Emerge as Central Players in Antibiotic Persister Survival
New genetic analysis in Escherichia coli reveals that the DNA repair hub proteins RecA and UvrD are essential for fluoroquinolone ...
Tag: DNA repair
PARP Inhibitor Plus Temozolomide Shows Promise in Relapsed Small-Cell Lung Cancer Trial
A phase Ib/II trial in China found that the oral PARP inhibitor HTMC0435 combined with temozolomide produced a manageable safety ...
Living Young to Live Long: The Shared Biology of Centuries-Old Species
A new review of 101 exceptionally long-lived species finds that extreme longevity is consistently linked to DNA maintenance, preserved stemness ...
Blood Pressure Drug Diltiazem Shows Promise Against Childhood Dementia
New research shows that the calcium channel blocker diltiazem suppresses parthanatos-related DNA damage and poly(ADP-ribose) accumulation in patient-derived cells from ...
Melatonin May Offer a Surprising Shield Against Skin Cancer, Review Suggests
A new review in the Archives of Dermatological Research proposes that melatonin, through antioxidant, DNA-repair, and circadian mechanisms, may serve ...
Insulin-Sensing FOXO Protein Guards the Genome After DNA Damage
New research in C. elegans shows that the FOXO transcription factor DAF-16 directly activates DNA repair genes to preserve genome ...
Ancient enzyme TyrRS may schedule nightly DNA repair in neurons, and aging breaks the clock
A new GeroScience review proposes that the tyrosine-sensing enzyme TyrRS schedules neuronal DNA repair across the sleep-wake cycle, and that ...
Cryo-EM Reveals How RNA Polymerase II Remodels and Stalls at Cisplatin DNA Crosslinks
Cryo-electron microscopy captures RNA polymerase II remodeling cisplatin-induced DNA interstrand crosslinks into a novel conformation that blocks the active site, ...
DNA Repair Protein RAD54L Protects Developing Egg and Sperm Precursors from Toxic Enzyme Traps
New research in mice reveals that the DNA repair factor RAD54L protects primordial germ cells by stabilizing the E3 ligase ...
Cell Cycle Breakdown Drives Sudden Bursts of Aneuploidy in Yeast Genomes
Experiments in hundreds of diploid yeast strains show that double losses of heterozygosity arise mainly from transient bursts of whole-chromosome ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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