CRISPR Screens Reveal DNMT3A’s Dual Role in Tumor Immune Evasion
In vivo CRISPR screens reveal that the epigenetic enzyme DNMT3A can both preserve and suppress tumor immune visibility, reshaping how ...
Tag: DNA Methylation
Reading the Genome One Molecule at a Time: A Practical Guide to Single-Molecule Genomics
Leading genome researchers have published a practical guide in Nature Reviews Molecular Cell Biology explaining how single-molecule genomics can reveal ...
Developmental Gene PAX9 Turns the Body’s Recycling System Into a Cancer Cell Killer
A new study shows that the developmental transcription factor PAX9 acts as a tumour suppressor in oral squamous cell carcinoma ...
Epigenetic Marks and Jumping Genes Decide Which Parental Genome Rules Mustard
New research shows that asymmetric DNA methylation, histone marks and transposable element insertions explain why one parental genome dominates gene ...
Cancer Must Silence Its Own Viral Alarm to Become Malignant, Review Argues
A Nature Reviews Cancer review argues that escaping the antiviral viral mimicry response triggered by derepressed transposable elements is a ...
Invisible Epigenetic Shadow: DNA Methylation Field Effect Detected Around Kidney Tumors
Researchers report DNA methylation alterations in histologically normal kidney tissue surrounding renal cell carcinoma, supporting a field effect that may ...
Lost Epigenetic Guardian CBX7 Emerges as Key Driver and Drug Target in Glioblastoma
A new review shows that the epigenetic regulator CBX7 acts as a tumor suppressor in glioblastoma, and that restoring its ...
Mitochondrial Enzyme SUCLG2 Emerges as a Tumor Suppressor in Colorectal Cancer
Researchers found that the mitochondrial enzyme SUCLG2 suppresses colorectal cancer by lowering SAM levels to demethylate GADD45G and reactivate p53-mediated ...
Epigenetic Age Tests Face Expert Backlash Over Reliability, Privacy and Ageism
A real-time Delphi study of French and Canadian experts finds widespread concern over the reliability, utility and legitimacy of direct-to-consumer ...
Galectin-9 Emerges as a Key Driver of Immune Evasion in Cervical Cancer Progression
A multi-omics study traces cervical carcinogenesis from normal tissue to invasive cancer and identifies galectin-9-driven immune evasion as a promising ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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