CagL Protein Polymorphism Fine-Tunes Helicobacter pylori Cancer Signaling
Analysis of 2,267 Helicobacter pylori genomes and gerbil infection experiments shows that a two-amino-acid polymorphism in the CagL pilus protein ...
Tag: DNA double-strand breaks
Microtubule Acetylation Softens the Nucleus to Speed DNA Break Repair
DNA damage triggers tubulin acetylation that displaces the perinuclear vimentin cage, allowing microtubule forces to ripple the nucleus and speed ...
RNA Chaperone ALYREF Hijacks Poly-ADP-Ribose at DNA Breaks and Slows Repair in Tumor Cells
Researchers report that the RNA-processing protein ALYREF binds poly-ADP-ribose at DNA double-strand breaks, delaying repair when overexpressed and marking a ...
Yeast Cells Reveal How Resting State Shields DNA from Toxic Antibiotic Zeocin
A new study shows that quiescent baker's yeast cells resist the radiomimetic antibiotic Zeocin far better than dividing cells, highlighting ...
Quiescent Yeast Cells Prove Most Vulnerable to Oxidative Stress from Menadione
A new study finds that quiescent Saccharomyces cerevisiae cells are dramatically more susceptible to menadione-induced oxidative stress and DNA damage ...
AI Trained on Fake Images Learns to Spot Real DNA Damage from Radiation
Researchers at the University of Malta and the University of Pittsburgh trained a modified U-Net on 95,000 synthetic microscopy images ...
Hidden Protein Trio Helps Cancer Cells Survive Radiation, Study Finds
A newly identified TIMELESS-SIRT1-Ku70 complex promotes assembly of the Ku DNA repair heterodimer, giving cancer cells resistance to radiation and ...
How Cells Choose Between DNA Repair Pathways—and Why It Matters for Cancer
A new review explains how the contest between BRCA1-BARD1 and the 53BP1 axis at DNA break ends determines whether cells ...
Somatic SNCA Gene Gains in Glia Drive Multiple System Atrophy
Researchers have shown that somatic copy number gains of the SNCA gene accumulate in oligodendrocytes of multiple system atrophy brains, ...
Loss of Checkpoint Kinase 2 Reshapes How Cells Repair Broken DNA
A new Cell Death & Discovery study shows that checkpoint kinase 2 deficiency alters how cells engage homologous recombination and ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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